Analysis of the efficacy and safety of endoscopic retrograde cholangiopancreatography for the treatment of pediatric pancreatobiliary diseases  

作　　者：Xue-Qi Wang Chi-Huan Kong Mao Ye Mei Diao 

机构地区：[1]Department of General Surgery,Children's Hospital Capital Institute of Pediatrics,Beijing 100020,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第12期3754-3763,共10页世界胃肠外科杂志（英文）

摘　　要：BACKGROUND Traditional surgical procedures are highly invasive and risky for children with pancreatic and biliary diseases.Endoscopic retrograde cholangiopancreatography(ERCP)has been used mostly in adults because it is a safe and effective surgical procedure.Its application in children will contribute to the treatment and prog-nosis of children with pancreatic and biliary diseases.AIM To analyze the efficacy and safety of ERCP for the treatment of pediatric pancre-atobiliary diseases.METHODS A retrospective study was performed using the medical records of 101 pediatric patients who received treatment for pancreatobiliary diseases at Children’s Hospital Capital Institute of Pediatrics from April 2022 to April 2024.The patients were divided into an observation group(n=52,treated with ERCP)and a control group(n=49,treated with traditional surgical methods).Diagnostic and therapeutic outcomes of ERCP were statistically analyzed.Treatment efficacy,time to resume eating,and hospital stay duration were compared between the two groups.Indicators of liver function were monitored preoperatively and one week postoperatively.Dynamic changes in C-reactive protein(CRP)and serum amylase levels were assessed preoperatively and at 6 and 24 hours postoper-atively.Postoperative complications were also compared.Logistic multivariate regression was used to analyze the independent effect of ERCP on outcomes.RESULTS For the observation group,36 and 16 patients were diagnosed with biliary and pancreatic diseases,respectively.Compared with the control group,the observa-tion group exhibited a higher overall effective rate(P<0.05),shorter times to resume eating,shorter hospital stays(P<0.05),and significantly improved postoperative liver function(P<0.05).CRP and serum amylase levels were significantly increased in both groups at 6 and 24 hours postoperatively(P<0.05),but were significantly lower in the observation group(P<0.05).The observation group also had a lower incidence of complications(P<0.05).ERCP was an independent factor affec

关 键 词：Endoscopic retrograde cholangiopancreatography Pediatric pancreatobiliary diseases EFFICACY Safety 

分 类 号：R657.4[医药卫生—外科学]