Effects of nocturnal snacks on body composition in patients with liver cirrhosis  

作　　者：Yong-Bo Yu Xiu-Juan Fu Guo-Fen Xu Ling-Yun Niu Ruo-Nan Duan Jia Yao Ning-Hui Zhao 

机构地区：[1]Department of Neurology,Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,Shanxi Province,China [2]Department of Gastroenterology,Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,Shanxi Province,China [3]Department of Nutrition,Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,Shanxi Province,China

出　　处：《World Journal of Hepatology》2024年第12期1458-1467,共10页世界肝病学杂志（英文）

基　　金：Supported by the Fundamental Research Program of Shanxi Province,No.202103021224341 and No.202203021222342;Science and Technology Cooperation and Exchange Special Project of Shanxi Province,No.202304041101048;Science Foundation of Shanxi Bethune Hospital,No.2023YJ07.

摘　　要：BACKGROUND Patients with liver cirrhosis are universally malnourished and the nocturnal snacks intervention is the currently recommended nutritional intervention for patients with liver cirrhosis.Body composition is an important indicator for the assessment of nutritional conditions.We investigated the effects of nocturnal snacks(200 kcal/day)for 3 months on body composition in patients with liver cirrhosis.Seventy patients with liver cirrhosis and 30 healthy controls were enrolled,and differences in body composition were detected using InBody 720,a body composition analyzer.The patients were further randomized into a normal diet group(three meals a day)and nocturnal snacks group(three meals a day+nocturnal snacks).The effect of nocturnal snacks on the body composition of patients with cirrhosis was assessed after 3 months of intervention.RESULTS Body fat mass(BFM),skeletal muscle mass(SMM),fat free mass,visceral fat area(VFA),and body cell mass(BCM)were significantly lower in the liver cirrhosis patients than in the healthy controls.After 3 months’intervention,BFM,VFA and BCM were significantly higher in the nocturnal snacks group than in the normal diet group,with no significant differences in total caloric intake and daily activity.However,there was no significant difference in SMM between the nocturnal snacks and normal diet groups.CONCLUSION Long-term nocturnal snacks may improve body composition indices such as BFM,VFA and BCM in patients with cirrhosis.However,the improvement was minor for SMM.

关 键 词：Liver cirrhosis MALNUTRITION Nocturnal snacks Body composition Nutritional intervention 

分 类 号：R575.2[医药卫生—消化系统]