Hepatitis B virus-induced cirrhosis: Mechanisms, global variations, and treatment advances  

作　　者：Jun-Ya Cheng Guan-Yue Shan Hui Wan Yi-Ying Liu Yu-Xin Zhang Wen-Na Shi Hai-Jun Li 

机构地区：[1]Department of Bioengineering,Pharmacy School of Jilin University,Changchun 130061,Jilin Province,China [2]Institute of Translational Medicine,The First Hospital of Jilin University,Changchun 130061,Jilin Province,China [3]Institute of Liver Diseases,Institute of Translational Medicine,The First Hospital of Jilin University,Changchun 130061,Jilin Province,China

出　　处：《World Journal of Hepatology》2024年第12期1515-1523,共9页世界肝病学杂志（英文）

基　　金：Supported by National Natural Science Foundation of China,No.81970529;the Natural Science Foundation of Jilin Province,No.20230508074RC and No.YDZJ202401218ZYTS.

摘　　要：We focus on hepatitis B virus(HBV)-induced cirrhosis,global differences,and the evolution of antiviral treatment strategies.Chronic HBV(CHB)infection affects more than 250 million people globally,leading to cirrhosis and hepatocellular carcinoma.The aim of this article was to synthesize the current understanding of the pathophysiological mechanisms and clinical consequences of HBV-induced cirrhosis,and explore differences in disease progression between geographic regions.Disease progression varies across regions due to differences in HBV subtypes,transmission routes,and immune responses.The challenge of late diagnosis and treatment,particularly in resource-limited areas,highlights the urgency and importance of CHB service expansion.Modern nucleos(t)ide ana-logues,such as tenofovir and entecavir,have emerged as the main therapeutic re-gimens to improve clinical outcomes in patients by suppressing viral replication and attenuating liver fibrosis.However,drug resistance challenges highlight the need for ongoing research and personalized treatment strategies.This article highlights the mechanisms and impact of cirrhosis progression in the context of CHB infection,aiming to reduce the incidence of cirrhosis and its serious con-sequences,thereby improving the long-term health of CHB patients worldwide,especially in Africa.

关 键 词：Chronic hepatitis B virus Hepatitis B virus-induced cirrhosis Nucleos(t)ide analogues 

分 类 号：R737.31[医药卫生—肿瘤]