Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction  

作　　者：Emir Bećirović Minela Bećirović SabinaŠegalo Amir Bećirović Semir Hadžić Kenana Ljuca Emsel Papić Lamija Ferhatbegović Malik Ejubović Amira JagodićEjubović Amila Kovčić ArminŠljivo Emir Begagić 

机构地区：[1]Department of Intensive Care,University Clinical Center Tuzla,Tuzla 75000,Bosnia and Herzegovina [2]Department of Nephrology,University Clinical Center Tuzla,Tuzla 75000,Bosnia and Herzegovina [3]Department of Laboratory Technologies,Faculty of Health Sciences,University of Sarajevo,Sarajevo 71000,Bosnia and Herzegovina [4]Department of Endocrinology,University Clinical Center Tuzla,Tuzla 75000,Bosnia and Herzegovina [5]School of Medicine,University of Tuzla,Tuzla 75000,Bosnia and Herzegovina [6]Department for Internal Diseases and Hemodialysis,Canton Hospital Zenica,Zenica 72000,Bosnia and Herzegovina [7]Department of Internal Medicine,Canton Hospital Zenica,Zenica 72000,Bosnia and Herzegovina [8]Department of Radiotherapy,University Clinical Center Tuzla,Tuzla 75000,Bosnia and Herzegovina [9]Department of Cardiology,University Clinical Center Sarajevo,Sarajevo 72000,Bosnia and Herzegovina [10]Department of General Medicine,University of Zenica,School of Medicine,Zenica 72000,Bosnia and Herzegovina

出　　处：《World Journal of Methodology》2025年第2期125-136,共12页世界方法学杂志（英文）

摘　　要：BACKGROUND Non-ST segment elevation myocardial infarction(NSTEMI)poses significant challenges in clinical management due to its diverse outcomes.Understanding the prognostic role of hematological parameters and derived ratios in NSTEMI patients could aid in risk stratification and improve patient care.AIM To evaluate the predictive value of hemogram-derived ratios for major adverse cardiovascular events(MACE)in NSTEMI patients,potentially improving clinical outcomes.METHODS A prospective,observational cohort study was conducted in 2021 at the Internal Medicine Clinic of the University Hospital in Tuzla,Bosnia and Herzegovina.The study included 170 patients with NSTEMI,who were divided into a group with MACE and a control group without MACE.Furthermore,the MACE group was subdivided into lethal and non-lethal groups for prognostic analysis.Alongside hematological parameters,an additional 13 hematological-derived ratios(HDRs)were monitored,and their prognostic role was investigated.RESULTS Hematological parameters did not significantly differ between non-ST segment elevation myocardial infarction(NSTEMI)patients with MACE and a control group at T1 and T2.However,significant disparities emerged in HDRs among NSTEMI patients with lethal and non-lethal outcomes post-MACE.Notably,neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)were elevated in lethal outcomes.Furthermore,C-reactive protein-to-lymphocyte ratio(CRP/Ly)at T1(>4.737)demonstrated predictive value[odds ratio(OR):3.690,P=0.024].Both NLR at T1(>4.076)and T2(>4.667)emerged as significant predictors,with NLR at T2 exhibiting the highest diagnostic performance,as indicated by an area under the curve of 0.811(95%CI:0.727-0.859)and OR of 4.915(95%CI:1.917-12.602,P=0.001),emphasizing its important role as a prognostic marker.CONCLUSION This study highlights the significant prognostic value of hemogram-derived indexes in predicting MACE among NSTEMI patients.During follow-up,NLR,PLR,and CRP/Ly offer important insights into the inflammatory proc

关 键 词：Hemogram-derived ratios Prognostic markers Neutrophil-to-lymphocyte ratio Myocardial infarction 

分 类 号：R747.2[医药卫生—神经病学与精神病学]