Gut microbiome and orthopaedic health:Bridging the divide between digestion and bone integrity  

作　　者：Naveen Jeyaraman Madhan Jeyaraman Priya Dhanpal Swaminathan Ramasubramanian Lavanya Ragavanandam Sathish Muthu Gabriel Silva Santos Lucas Furtado da Fonseca JoséFábio Lana 

机构地区：[1]Department of Orthopaedics,ACS Medical College and Hospital,Dr MGR Educational and Research Institute,Chennai 600077,Tamil Nadu,India [2]Department of Orthopaedics,Orthopaedic Research Group,Coimbatore 641045,Tamil Nadu,India [3]Department of Orthopaedics,Brazilian Institute of Regenerative Medicine,Indaiatuba 13334-170,São Paulo,Brazil [4]Department of General Medicine,Government Medical College,Omandurar Government Estate,Chennai 600002,Tamil Nadu,India [5]Department of Pharmacology,Faculty of Medicine-Sri Lalithambigai Medical College and Hospital,Dr MGR Educational and Research Institute,Chennai 600095,Tamil Nadu,India [6]Department of Orthopaedics,Government Medical College and Hospital,Karur 639004,Tamil Nadu,India [7]Department of Biotechnology,Karpagam Academy of Higher Education,Coimbatore 641021,Tamil Nadu,India

出　　处：《World Journal of Orthopedics》2024年第12期1135-1145,共11页世界骨科杂志（英文）

摘　　要：The gut microbiome,a complex ecosystem of microorganisms in the digestive tract,has emerged as a critical factor in human health,influencing metabolic,immune,and neurological functions.This review explores the connection between the gut microbiome and orthopedic health,examining how gut microbes impact bone density,joint integrity,and skeletal health.It highlights mechanisms linking gut dysbiosis to inflammation in conditions such as rheumatoid arthritis and osteoarthritis,suggesting microbiome modulation as a potential therapeutic strategy.Key findings include the microbiome’s role in bone metabolism through hormone regulation and production of short-chain fatty acids,crucial for mineral absorption.The review also considers the effects of diet,probiotics,and fecal microbiota transplantation on gut microbiome composition and their implications for orthopedic health.While promising,challenges in translating microbiome research into clinical practice persist,necessitating further exploration and ethical consideration of microbiome-based therapies.This interdisciplinary research aims to link digestive health with musculoskeletal integrity,offering new insights into the prevention and management of bone and joint diseases.

关 键 词：Gut microbiome Orthopaedic health Bone density DYSBIOSIS Inflammation Microbiome modulation 

分 类 号：R687.3[医药卫生—骨科学]