Ulcerative colitis and bullous pemphigoid:Direct association or a medication side effect:A case report  

作　　者：Gaelle-Christie Haddad Anthony El Dada Sergio Sbeih Tony Kazzi Karam Karam Louis A Chaptini 

机构地区：[1]Department of Internal Medicine,University of Balamand,Beirut 100,Lebanon [2]Department of Medicine,Gastroenterology,University of Balamand,Balamand 100,Lebanon [3]Department of Medicine,Digestive Diseases,Yale School of Medicine,New Haven,CT 06510,United States

出　　处：《World Journal of Clinical Cases》2025年第9期47-52,共6页世界临床病例杂志（英文）

摘　　要：BACKGROUND Bullous pemphigoid(BP)is an autoimmune blistering skin disorder.It is associated with other autoimmune disorders and the use of certain drugs.We describe a case of BP in a patient with ulcerative colitis(UC)treated with mesalamine.CASE SUMMARY A 38-year-old male patient with UC and a history of multiple flares was maintained on mesalamine with good clinical response.One year after starting mesalamine,he sought medical care following the onset of a severe itchy rash of several weeks’duration with a recent appearance of skin bullae.A biopsy of the skin revealed subepidermal blistering dermatitis with focal eosinophilic spongiosis.Direct immunofluorescence studies revealed linear IgG and C3 immune reactant deposits at the dermoepidermal junction,consistent with the diagnosis of BP.Prednisone therapy alleviated his symptoms.However,tapering prednisone led to re-eruption of the bullae.CONCLUSION BP should be considered when patients with UC develop skin manifestations.Although BP is not one of the extraintestinal manifestations of UC,there may be an association between these two conditions.Whether treatment with mesalamine or other therapeutic agents plays a role in the development of BP remains unclear.

关 键 词：Bullous pemphigoid Ulcerative colitis Autoimmune disorders Skin manifestations in inflammatory bowel diseases MESALAMINE Case report 

分 类 号：R576[医药卫生—消化系统] R574.62[医药卫生—内科学]