Creeping fat and gut microbiota in Crohn’s disease  

作　　者：Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen CS De Oliveira Luiz C Di Stasi Ligia Y Sassaki 

机构地区：[1]Verum Ingredients,Botucatu Technology Park,Botucatu 18605-525,São Paulo,Brazil [2]Department of Surgery,Faculty of Medical Sciences,State University of Campinas,Campinas 13083-970,São Paulo,Brazil [3]Department of Gastroenterology,Faculty of Medical Sciences,University of Campinas,Campinas 13083-970,São Paulo,Brazil [4]Department of Internal Medicine,Medical School,São Paulo State University,Botucatu 18618-686,São Paulo,Brazil [5]Department of Biophysics and Pharmacology,Institute of Biosciences,São Paulo State University,Botucatu 18618-689,São Paulo,Brazil

出　　处：《World Journal of Gastroenterology》2025年第1期16-23,共8页世界胃肠病学杂志（英文）

基　　金：Supported by the Postdoctoral Scholarship Grant,No.5552/2024 PROPG/PROPE N°06/2024.

摘　　要：In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of Crohn’s disease(CD).CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental factors.Gut microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of CD.Further,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in CD pathogenesis,inflammation,and fibrosis.The bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing CD progression.Although creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to complications.Modulating gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing CD.However,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and CD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with CD.

关 键 词：Creeping fat Mesenteric adipose tissue Gut microbiota Crohn’s disease Inflammatory bowel disease 

分 类 号：R735.34[医药卫生—肿瘤]