Predictive value of nutritional status and serological indicators in elderly patients with mild cognitive impairment  

作　　者：Ying Yang Shou-Rong Lu Qiao Xu Jie Yu Zhuo Wang Bing-Shan Zhang Kan Hong 

机构地区：[1]Department of Geriatrics,The Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi 214023,Jiangsu Province,China [2]Wuxi Medical Center,Nanjing Medical University,Wuxi People's Hospital,Wuxi 214023,Jiangsu Province,China

出　　处：《World Journal of Psychiatry》2024年第12期1925-1935,共11页世界精神病学杂志（英文）

基　　金：Supported by The Commissioned Project of the 2023 Elderly Appropriate Technology Special Fund of Jiangsu Geriatric Society,No.JSLY202302;The Scientific Research Project of Jiangsu Provincial Health Commission,No.BJ21008;The 2023 Specialized Disease Queue Research Project of Wuxi Medical Center,Nanjing Medical University,No.WMCC202311;Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee,No.HB2023003.

摘　　要：BACKGROUND Mild cognitive impairment(MCI)in elderly individuals is a transitional stage between normal cognition and dementia.Understanding the risk factors for MCI and identifying those at high risk are extremely important for the elderly population.AIM To analyze the risk factors for MCI in the elderly population and construct a clinical prediction model.METHODS Total 295 elderly individuals presenting with memory loss diagnosed at Wuxi People's Hospital between March 2021 and March 2024 were included.Comprehensive demographic,clinical,and serological data were collected for analysis.Participants were categorized into either an MCI group or a normal group based on their performance on the Montreal Cognitive Assessment Scale.An elaborate clinical predictive model was developed to predict the likelihood of MCI in stroke patients;its accuracy was evaluated using area under curve values and calibration curves.RESULTS The results of the study showed that old age,hypertension,diabetes,hyperlipidemia,smoking,high-salt diet,high-cholesterol diet,decreased red blood count,increased neutrophil lymphocyte ratio and increased low-density lipoprotein cholesterol were risk factors for the onset of MCI,with A high vitamin diet and elevated high-density lipoprotein cholesterol being protective factors.In addition,the prediction model constructed in this study exhibits good degrees of differentiation and calibration.CONCLUSION The risk factors for MCI are diverse.Early identification of individuals at high risk of MCI can better intervene and improve their quality of life of MCI patients.

关 键 词：Nutritional status Serum detection Cognitive impairment Mild symptom FORECAST Risk factor 

分 类 号：R749.1[医药卫生—神经病学与精神病学]