Effect of comprehensive intervention model based on drugpsychology-society-skills on medication compliance and cognitive ability of chronic schizophrenia patients  

作　　者：Hai-Jun Wang Wei Chen Xiao-Lin Yan Qian-Ying Huang Wei-Dong Xu 

机构地区：[1]The Fourth Ward,The Third People’s Hospital of Yongkang,Yongkang 321300,Zhejiang Province,China [2]Department of Psychiatry,Zhejiang University School of Medicine,and the Collaborative Innovation Center for Brain Science,Zhejiang University Affiliated SIR Run Run Shaw Hospital,Hangzhou 311100,Zhejiang Province,China [3]Department of Laboratory Medicine,The Third People’s Hospital of Yongkang,Yongkang 321300,Zhejiang Province,China [4]The Third Ward,The Third People’s Hospital of Yongkang,Yongkang 321300,Zhejiang Province,China

出　　处：《World Journal of Psychiatry》2024年第12期1947-1955,共9页世界精神病学杂志（英文）

摘　　要：BACKGROUND The intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia was unknown.AIM To explore the intervention value of a drug-psycho-social-skill model on medication compliance and cognitive ability in patients with chronic schizophrenia.METHODS Overall,98 out-patients and in-patients with chronic schizophrenia treated in our hospital from February 2022 to January 2023 were included and randomly divided into the study(50 patients)and control groups(48 patients).For 3 months,the control group was treated with conventional drugs,and the research group with a comprehensive intervention model of drug-psychology-society-skills.Data were obtained for the mini mental assessment scale(MMSE),Montreal cognitive assessment scale(MoCA),positive and negative symptom scale,insight and treatment attitude scale,cognitive ability scale and social skills[personal and social function scale(PSP)].The adverse reactions were observed.RESULTS After the intervention,the MMSE and MoCA scores improved in both groups.MoCA scores in the study group(26.58±3.21)were significantly(P<0.05)higher than those in the control group(24.68±3.02),MMSE scores were not significantly higher.Post-intervention,positive and negative symptom scores improved in both groups,and the positive and negative symptom scores in the study group[(12.01±2.58)and(32.51±2.11)]were significantly(P<0.05)different than those in the control group[(14.54±2.33)and(33.74±2.55)].Post-intervention,insight and treatment attitudes questionnaire scores of both groups were improved and compared with the control group(7.97±3.02),the study group(13.56±6.35)had significantly(P<0.05)higher scores.Post-intervention,the MATRICS consensus cognitive battery score of both groups was improved and compared with the control group(38.44±6.23),the score of the study group was significantly(P<0.05)increased(43.51±6.01).Post-intervention,the PSP score of the study group(78.38±6.63)was significantly(P<0

关 键 词：Drug-psychology-society-skill Comprehensive intervention model Medication compliance SELF-KNOWLEDGE Cognitive ability 

分 类 号：R749.3[医药卫生—神经病学与精神病学]