Heart abnormality associates with a wide spectrum of psychiatric disorders:Evidence from Mendelian randomization analyses  

作　　者：Xue-Shi Chen Zi-Yan Song Xuan-Long Chen Yi-Ming Bo Li-Liang Li 

机构地区：[1]Department of Forensic Medicine,School of Basic Medical Sciences,Fudan University,Shanghai 200032,China

出　　处：《World Journal of Psychiatry》2024年第12期1988-1991,共4页世界精神病学杂志（英文）

基　　金：Supported by the National Natural Science Foundation of China,No.82070285,No.82322033 and No.82470265.

摘　　要：Psychiatric disorders and heart abnormality are closely interconnected.Previous knowledge has been well-established that psychiatric disorders can lead to increased cardiovascular morbidity and even sudden cardiac death.Conversely,whether heart abnormality contributes to psychiatric disorders remains rarely studied.The work by Zhang et al pointed out that chronic heart failure had effects on the anxiety and depression(AD)severity,and indices including left ventricular ejection fraction,N-terminal pro-brain natriuretic peptide and interleukin-6 were independent risk factors for AD severity.In addition to the aforementioned AD,we herein find that heart failure might additionally impact the development of autism spectrum disorder and post-traumatic stress disorder(albeit P>0.05),and significantly protects against the presence of attention deficit hyperactivity disorder(ADHD),[odds ratio(OR)=0.61,P=0.0071]by using a Mendelian randomization analysis.Bradycardia is also a protective factor for ADHD(OR=0.61,P=0.0095),whereas hypertrophic cardiomyopathy is a mild risk factor for schizophrenia(OR=1.02,P=0.032).These data suggest a wide spectrum of psychiatric disorders secondary to heart abnormality,and we highlight more psychiatric care that should be paid to patients with heart abnormality.

关 键 词：Psychiatric disorders SCHIZOPHRENIA Heart abnormality Heart failure Mendelian randomization analyses 

分 类 号：R749[医药卫生—神经病学与精神病学]