Mesenchymal stem cell therapy in atherosclerosis:A bibliometric and visual analysis  

作　　者：Xing Cheng Ya-Ling Li Heng Wang Rui-Jing Zhang Ke-Yi Fan Xiao-Tong Qi Guo-Ping Zheng Hong-Lin Dong 

机构地区：[1]Department of Vascular Surgery,The Second Hospital of Shanxi Medical University,Taiyuan 030000,Shanxi Province,China [2]Centre for Transplant and Renal Research,Westmead Institute for Medical Research,The University of Sydney,Sydney 2145,New South Wales,Australia [3]Department of Nephrology,The Second Hospital of Shanxi Medical University,Taiyuan 030000,Shanxi Province,China

出　　处：《World Journal of Stem Cells》2024年第12期1062-1085,共24页世界干细胞杂志（英文）

基　　金：Supported by the Regional Cooperation Program of Shanxi Province,China,No.202204041101038;the Construction and Demonstration of the Molecular Diagnosis and Treatment Platform for Vascular Diseases in Shanxi Province,China,No.SCP-2023-17;Translational Medicine Engineering Research Center for Vascular Diseases of Shanxi Province,China,No.2022017.

摘　　要：BACKGROUND Mesenchymal stem cells(MSCs)are capable of self-renewal and differentiation,and extensive studies have demonstrated their therapeutic potential in atherosclerosis(AS).AIM To conduct a bibliometric analysis of studies on the use of MSC therapy for AS over the past two decades,assess key trends and provide insights for future research directions.METHODS We systematically searched the Web of Science Core Collection database for articles published between 1999 and 2023,yielding a total of 556 articles.Visual representation and bibliometric analysis of information and trends were facilitated using CiteSpace,the R package‘bibliometrix’and VOSviewer.RESULTS The analyzed articles were predominantly from 52 countries/regions,with prominent contributions from China and the United States.A cohort of 3057 authors contributed to these publications,with the works of Libby P distinguished by their influence and citation count.Int J Mol Sci has emerged as the journal with the highest publication volume,prominently disseminating influential papers and identifying citation outbreaks.Furthermore,our analysis identified current research hotspots within the field,focusing on vascular progenitor cells,inflammatory mechanisms,and extracellular vesicles.Emerging research frontiers,such as extracellular vesicles and oxidative stress,have been highlighted as areas of burgeoning interest.Finally,we offer perspectives on the status of research and future directions of MSC therapy in AS.CONCLUSION This comprehensive analysis provides valuable insights for advancing scientific research on MSC therapy for AS.By elucidating pivotal trends and research directions,this study aimed to foster innovation and promote the progress of disciplines in this field,thereby contributing to advancing scientific knowledge and clinical practice.

关 键 词：ATHEROSCLEROSIS Treatment strategy BIBLIOMETRICS Visual analysis CITESPACE 

分 类 号：R563.1[医药卫生—呼吸系统]