Interplay and therapeutic implications of colorectal cancer stem cells,tumor microenvironment,and gut microbiota  

作　　者：Hui Zhang Bo-Tao Xu Di-Ping Luo Tie-Fei He 

机构地区：[1]Department of Emergency Surgery,Zhuji People’s Hospital,Zhuji 311800,Zhejiang Province,China [2]Department of Cardiothoracic Surgery,Zhuji People’s Hospital,Zhuji 311800,Zhejiang Province,China [3]Department of Vascular Surgery,Zhuji People’s Hospital,Zhuji 311800,Zhejiang Province,China

出　　处：《World Journal of Stem Cells》2024年第12期1110-1114,共5页世界干细胞杂志（英文）

摘　　要：This article discusses the interplay between colorectal cancer(CRC)stem cells,tumor microenvironment(TME),and gut microbiota,emphasizing their dynamic roles in cancer progression and treatment resistance.It highlights the adaptability of CRC stem cells,the bidirectional influence of TME,and the multifaceted impact of gut microbiota on CRC.The manuscript proposes innovative therapeutic strategies focusing on these interactions,advocating for a shift towards personalized and ecosystem-targeted treatments in CRC.The conclusion underscores the importance of continued research in these areas for developing effective,personalized therapies.

关 键 词：Colorectal cancer Stem cells Tumor microenvironment Gut microbiota Treatment resistance Therapeutic strategies Personalized medicine Cancer ecosystem Research advancements 

分 类 号：R735.34[医药卫生—肿瘤]