外周血TRX-1、VEGF联合NO/ET-1预测老年急性脑梗死患者并发血管性痴呆的价值研究  

The value of peripheral blood TRX-1,VEGF combined with NO/ET-1 in predicting vascular dementia in elderly patients with acute cerebral infarction

作　　者：叶威 王志辉 彭敏 任迪 曾乐平[4] 粟伟栋 YE Wei;WANG Zhihui;PENG Min;REN Di;ZENG Leping;SU Weidong(School of Basic Medicine,Changsha Health Vocational College Changsha Hunan 410699,China)

机构地区：[1]长沙卫生职业学院基础医学部,湖南长沙410699 [2]长沙卫生职业学院临床学院,湖南长沙410699 [3]长沙市第八医院神经外科,湖南长沙410023 [4]中南大学湘雅医学院人体解剖与神经生物学系,湖南长沙410013

出　　处：《中国急救复苏与灾害医学杂志》2024年第12期1605-1608,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：湖南省创新型省份建设专项项目(编号:S2021JJKWLH0364)。

摘　　要：目的探讨外周血硫氧还蛋白-1(TRX-1)、血管内皮生长因子(VEGF)联合一氧化氮(NO)/内皮素-1(ET-1)比值(NO/ET-1)对老年急性脑梗死(ACI)患者并发血管性痴呆(VaD)的预测价值。方法回顾性收集2021年5月—2023年5月长沙市第八医院104例老年ACI患者临床资料,根据是否并发VaD,将患者分为VaD组(n=38)及Non-VaD组(n=66),比较两组临床资料,多因素Logistic回归模型分析ACI并发VaD的危险因素,采用受试者工作特征(ROC)曲线分析血清TRX-1、VEGF水平及NO/ET-1对老年ACI患者并发VaD的预测价值。结果VaD组年龄、超敏C-反应蛋白(hs-CRP)及糖尿病、高血压病、高脂血症比例高于Non-VaD组,TRX-1、VEGF、NO/ET-1低于Non-VaD组(P<0.05);年龄、糖尿病、高血压病、高脂血症及血清TRX-1、VEGF、NO/ET-1均是影响ACI患者发生VaD的独立危险因素(P<0.05)。VaD组、Non-VaD组血清TRX-1、VEGF、NO/ET-1表达水平均呈正相关;TRX-1、VEGF、NO/ET-1联合预测ACI患者并发VaD的AUC为0.713。结论血清TRX-1、VEGF、NO/ET-1是老年ACI患者并发VaD的独立危险因素,可作为预测VaD的生物标志物。Objective Exploring the predictive value of peripheral blood thioredoxin-1(TRX-1),vascular endothelial growth factor(VEGF)combined with nitric oxide(NO)/endothelin-1(ET-1)ratio(NO/ET-1)in predicting vascular dementia(VaD)in elderly patients with acute cerebral infarction(ACI).Methods Retrospective collection of clinical data from 104 elderly ACI patients at Changsha Eighth Hospital from May 2021 to May 2023.Patients were divided into VaD group(n=38)and Non-VaD group(n=66)based on whether they were complicated with VaD.The clinical data of the two groups were compared,and a multivariate Logistic regression model was used to analyze the risk factors for ACI complicated with VaD.Receiver Operating Characteristic(ROC)curves were used to analyze the predictive value of serum TRX-1,VEGF levels,and NO/ET-1 for VaD in elderly ACI patients.Results The age,hs CRP,diabetes,hypertension and hyperlipidemia in VaD group were higher than those in Non-VaD group,while TRX-1,VEGF,NO/ET-1 were lower than those in Non-VaD group(P<0.05);Age,diabetes,hypertension,hyperlipidemia and serum TRX-1,VEGF,NO/ET-1 were all independent risk factors for VAD in ACI patients(P<0.05).The expression levels of serum TRX-1,VEGF,and NO/ET-1 were positively correlated in both VaD and Non-VaD groups;The combined prediction of TRX-1,VEGF,and NO/ET-1 for VaD in ACI patients has an AUC of 0.713.Conclusion Serum TRX-1,VEGF,and NO/ET-1 are independent risk factors for VaD in elderly ACI patients and can serve as biomarkers for predicting VaD.

关 键 词：急性脑梗死合并血管性痴呆 硫氧还蛋白-1 血管内皮生长因子 一氧化氮 内皮素-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学]