基于合成磁共振成像鉴别子宫内膜癌与正常子宫外肌层的可行性研究  

Feasibility of Quantitative Synthetic MRI for Discriminating Endometrial Carcinoma from Peripheral Myometrium

作　　者：郑作锋[1] 杨家斐 张东坡[1] 马隽 吴希兰 ZHENG Zuo-feng;YANG Jia-fei;ZHANG Dong-po;MA Jun;WU Xi-lan(Department of Radiology,Beijing Chuiyangliu Hospital,Beijing 100022,China;Department of Pathology,Beijing Chuiyangliu Hospital,Beijing 100022,China)

机构地区：[1]北京市垂杨柳医院放射科,北京100022 [2]北京市垂杨柳医院病理科,北京100022

出　　处：《中国CT和MRI杂志》2024年第12期138-140,共3页Chinese Journal of CT and MRI

摘　　要：目的基于合成磁共振成像(SyMRI),评估子宫内膜癌(ECa)与正常子宫外肌层(nPM)的T1、T2及质子密度(PD)的差异性。方法回顾性分析16例行子宫常规MRI和SyMRI扫描的ECa患者。使用MAGIC软件于合成横断位T2WI勾划感兴趣区(ROI)。ECa与nPM定量值比较采用独立样本t检验。使用受试者工作特征曲线(ROC)评估定量值在鉴别ECa与nPM的诊断价值。结果nPM的T1、T2值低于ECa(P=0.001,P<0.001)。PD值在nPM与ECa之间无显著差异(P=0.177)。在鉴别ECa与nPM方面,T2值ROC曲线下面积(AUC)显著高于T1值(P=0.028)和PD值(P=0.002)。T1值和PD值AUC无显著差异(P=0.153)。T1、T2、PD联合效应在鉴别nPM与ECa方面显著高于T1值和PD值(P=0.028,P=0.002)。结论SyMRI技术可定量评估ECa和正常子宫肌层,其中T2值对鉴别ECa与nPM的价值高于T1及PD值。Objective To investigate the feasibility of using T1,T2,and proton density(PD)derived from synthetic MRI for discriminating endometrial carcinoma(ECa)from normal appearing peripheral myometrium(nPM)of ECa patients.Methods 16 patients with ECa underwent both conventional pelvic MRI and synthetic MRI were included in our study.Regions of interest(ROI)were placed over ECa and nPM based on synthetic T2-weighted images.Independent sample t-test was used to evaluate the differences of T1,T2,and PD values between ECa and nPM.Receiver operating characteristic(ROC)curve was used to assess the diagnostic effectiveness of each quantitative parameter in differentiating ECa from nPM.Results T1,T2 values of nPM were significantly lower than that of ECa(P=0.001,P<0.001,respectively)and no significant difference of PD value was found between ECa and nPM(P=0.177).In differentiating ECa from nPM,the Area Under the Curve(AUC)of T2 value(AUC=1.000)was significantly higher than that of T1(AUC=0.831)and PD(AUC=0.651)values(P=0.028 and 0.002,respectively).No significant differences were demonstrated between the AUC of T1 and PD values(P=0.153).The combination of T1,T2,and PD values showed a significantly higher diagnostic performance compared with T1 or PD values in discriminating ECa from nPM(P=0.028 and 0.002,respectively).Conclusion Synthetic MRI can be potentially used as a new method for quantification of T1,T2,and PD values of normal uterine tissues and ECa.T2 value was more useful than T1 and PD values in discriminating ECa from nPM of cancer patients.

关 键 词：合成磁共振成像 子宫内膜癌 子宫 弛豫时间 质子密度 

分 类 号：R737.3[医药卫生—肿瘤] R816.91[医药卫生—临床医学]