套细胞淋巴瘤合并自身免疫性溶血性贫血一例并文献复习  

Mantle Cell Lymphoma Complicated with Autoimmune Hemolytic Anemia:Report of One Case and Review of Literature

作　　者：张春元[1] 陈湘磊[2] ZHANG Chun-yuan;CHEN Xiang-lei(Department of Laboratory,Yidu Central Hospital of Weifang,Qingzhou 262500,Shandong Province,China;Department of Hematology,Yidu Central Hospital of Weifang,Qingzhou 262500,Shandong Province,China)

机构地区：[1]潍坊市益都中心医院检验科,山东青州262500 [2]潍坊市益都中心医院血液科,山东青州262500

出　　处：《罕少疾病杂志》2024年第12期8-9,共2页Journal of Rare and Uncommon Diseases

基　　金：潍坊市卫健委科研项目(WFWSJK-2021-249,WFWSJK-2020-302)。

摘　　要：目的探讨以自身免疫性溶血性贫血为首发表现套细胞淋巴瘤的临床特征及预后。方法回顾性分析潍坊市益都中心医院收治的1例以自身免疫性溶血性贫血为首发表现套细胞淋巴瘤的临床资料,并复习相关文献。结果患者以胸闷、乏力就诊我院,血常规、血髓象、骨髓病理、骨髓免疫分型、骨髓FISH检查综合诊断为套细胞淋巴瘤合并自身免疫性溶血性贫血,2周期RCHOP免疫化疗后溶血性贫血缓解,6周期RCHOP免疫化疗后套细胞淋巴瘤达完全缓解。结论套细胞淋巴瘤合并自身免疫性溶血性贫血病例罕见,易漏诊,延误治疗;自身免疫性溶血性贫血患者,应及时行骨髓检查;以免疫化疗为主的综合治疗可控制溶血,改善患者预后。Objective To investigate the clinical features and prognosis of mantle cell lymphoma complicated with autoimmune hemolytic anemia.Methods The clinical data of a patient with mantle cell lymphoma complicated with autoimmune hemolytic anemia in Weifang Yidu Central Hospital were retrospectively analyzed,and the relevant literature was reviewed.Results The patient complains of fatigue and chest tightness was referred to hospital.Complete blood counts,bone marrow aspiration and biopsy,immunophenotype,Fluorescent in situ hybridization(FISH)were performed.Finally,a diagnosis of mantle cell lymphoma complicated with autoimmune hemolytic anemia was confirmed.After two cycles of RCHOP,AIHA achieved complete remission.After six cycles of RCHOP,MCL achieved complete remission.Conclusions Mantle cell lymphoma associated with AIHA is a rare entity.So,the diagnosis and treatment often be delayed.Bone marrow evaluation is indicated for patients presented with AIHA.Chemotherapy is effective for control of AIHA and improve prognosis.

关 键 词：淋巴瘤 自身免疫性溶血性贫血 免疫化疗 预后 

分 类 号：R733.4[医药卫生—肿瘤]