妊娠相关性乳腺癌发病危险因素的病例-对照研究  

A Case-control Study on Risk Factors of Pregnancy Associated Breast Cancer

作　　者：谢岩桀 曲妮娜[2] 刘核秀 毕梦露 曹小丽[2] XIE Yan-jie;QU Ni-na;LIU He-xiu;BI Meng-lu;CAO Xiao-li(School of Medical Imaging,Binzhou Medical University,Yantai 264003,Shandong Province,China;Department of Ultrasound,Yantai Yuhuangding Hospital,Yantai 264000,Shandong Province,China;School of Medical Imaging,Weifang Medical University,Weifang 261021,Shandong Province,China)

机构地区：[1]滨州医学院医学影像学院,山东烟台264003 [2]烟台毓璜顶医院超声科,山东烟台264000 [3]潍坊医学院医学影像学院,山东潍坊261021

出　　处：《罕少疾病杂志》2024年第12期72-74,共3页Journal of Rare and Uncommon Diseases

基　　金：省级自然科学基金资助项目(ZR2021MH398)。

摘　　要：目的通过病例-对照研究探索妊娠相关乳腺癌(pregnancy associated breast cancer,PABC)的发病危险因素。方法选取烟台市毓璜顶医院2015年1月至2023年8月57例PABC患者作为PABC组,根据年龄按1∶1频数匹配同期来我院查体的57例健康人群作为对照组,对比两组的月经生育史、二手烟史、恶性肿瘤家族史等,采用单因素及多因素Logistic回归分析筛选出PABC的独立危险因素。结果单因素分析结果显示首次妊娠年龄、初潮年龄与首次妊娠年龄的间隔、流产史、二手烟史、恶性肿瘤家族史与PABC的发生相关(P<0.05)。多因素Logistic回归分析显示,初潮年龄与首次妊娠年龄的间隔(OR=1.461,95%CI:1.006~2.122)、流产史(OR=2.775,95%CI:1.109~6.942)、二手烟史(OR=2.857,95%CI:1.111~7.351)、恶性肿瘤家族史(OR=5.424,95%CI:1.215~24.212)是PABC的独立危险因素(P<0.05)。结论初潮年龄与首次妊娠年龄的间隔、流产史、二手烟史及恶性肿瘤家族史是PABC发病的独立危险因素,应尽早识别PABC高危人群,及时给予有效的干预和诊疗措施。Objective To investigate risk factors of pregnancy associated breast cancer(PABC)on the basis of case-control study.Methods 57 patients with PABC in Yantai Yuhuangding Hospital from January 2015 to August 2023 were selected as the PABC group,and 57 healthy people who were examined in our hospital as the control group,which were matched by age with a ratio of about 1:1.Demo graphic characteristics.The menstrual and reproductive history,second-hand smoking history,and family history of malignant tumors,and of the two groups were compared.Univariate and multivariate logistic regression analysis was performed to screen out independent risk factors.Results Univariate analysis showed that age at first birth,the age interval between menarche and the first pregnancy(standardized age at first birth,SAFB),history of miscarriage,history of second-hand smoking,and family history of malignant tumors were statistically significant(P<0.05).Multivariate logistic regression analysis showed that the age interval between menarche and the first pregnancy(OR=1.461,95%CI:1.006~2.122),history of miscarriage(OR=2.775,95%CI:1.109~6.942),history of second-hand smoking(OR=2.857,95%CI:1.111~7.351),and family history of malignant tumors(OR=5.424,95%CI:1.215~24.212)were independent risk factors for PABC(P<0.05).Conclusion The age interval between menarche and the first pregnancy,history of miscarriage,history of second-hand smoking,and family history of malignant tumors are independent risk factors for the onset of PABC.It is necessary to identify high-risk groups of PABC as soon as possible and provide effective intervention and diagnosis and treatment measures in a timely manner.

关 键 词：妊娠相关性乳腺癌 危险因素 病例—对照研究 

分 类 号：R737.9[医药卫生—肿瘤]