血清ALT、AST、TBIL联合检测在原发性肝癌诊断中的应用价值  

Application Value of Combined Detection of Serum ALT,AST and TBIL in the Diagnosis of Primary Liver Cancer

作　　者：陈婷 熊龙江 邓琼 熊丹 CHEN Ting;XIONG Long-jiang;DENG Qiong;XIONG Dan(First People's Hospital of Fuzhou,Fuzhou 344000,Jiangxi Province,China;Second People's Hospital of Fuzhou,Fuzhou 344100,Jiangxi Province,China)

机构地区：[1]抚州市第一人民医院,江西抚州344000 [2]抚州市第二人民医院,江西抚州344100

出　　处：《罕少疾病杂志》2024年第12期77-78,共2页Journal of Rare and Uncommon Diseases

基　　金：抚州市社会发展指导性科技计划项目(抚科社字〔2022〕9号-16)。

摘　　要：目的探究血清谷丙转氨酶(ALT)、门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)联合检测在原发性肝癌(PHC)诊断中的应用价值。方法回顾性分析2020年4月至2021年12月于抚州市第一人民医院就诊的40例PHC患者临床资料,将其纳入PHC组,并收集同期就诊的40例肝硬化患者临床资料,纳入肝硬化组。所有患者就诊后均进行ALT、AST、TBIL检测。比较两组患者各指标水平,并绘制受试者工作曲线(ROC),分析血清ALT、AST、TBIL联合检测在PHC诊断中的应用价值。结果PHC组的血清ALT、AST、TBIL水平高于肝硬化组,差异有统计学意义(P<0.05)。绘制ROC曲线,结果显示,血清ALT、AST、TBIL单一检测及联合检测诊断PHC的AUC为0.791、0.851、0.841、0.944,有一定预测价值,且当血清ALT、AST、TBIL的cut-off值取45.235U/L、54.350U/L、59.915μmol/L,可获得最佳诊断价值。结论血清ALT、AST、TBIL联合检测可有效鉴别PHC与肝硬化,对PHC具有较高诊断价值。Objective To explore the value of combined detection of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bilirubin(TBIL)in the diagnosis of primary liver cancer(PHC).Methods The clinical data of 40 patients with PHC who were treated in Fuzhou First People's Hospital from April 2020 to December 2021 were retrospectively analyzed,and they were included in the PHC group,collect clinical data from 40 patients with liver cirrhosis who received treatment during the same period and include them in the liver cirrhosis group.All patients were tested for ALT,AST and TBIL after treatment.The levels of each index in the two groups were compared,and the receiver operating curve(ROC)was drawn to analyze the application value of the combined detection of serum ALT,AST and TBIL in the diagnosis of PHC.Results The levels of serum ALT,AST and TBIL in the PHC group were higher than those in the liver cirrhosis group,and the difference was statistically significant(P<0.05).The ROC curve was drawn,and the results showed that the AUC of serum ALT,AST,TBIL single detection and combined detection for the diagnosis of PHC were 0.791,0.851,0.841,and 0.944,which had certain predictive value,and when the cut-off values of serum ALT,AST,and TBIL were taken as 45.235U/L,54.350U/L,59.915μmol/L,the best diagnostic value can be obtained.Conclusion The combined detection of serum ALT,AST and TBIL can effectively distinguish PHC from liver cirrhosis,and has high diagnostic value for PHC.

关 键 词：原发性肝癌 谷丙转氨酶 门冬氨酸氨基转移酶 总胆红素 

分 类 号：R735.7[医药卫生—肿瘤]