结直肠癌白蛋白碱性磷酸酶比值的表达研究  

Value of Albumin Alkaline Phosphatase Ratio in the Prognosis Evaluation of Postoperative Chemotherapy in Patients with Colorectal Cancer

作　　者：张贤 童金凤 江政松 汤蕾 夏云[1] 王志[1] ZHANG Xian;TONG Jin-feng;JIANG Zheng-song;TANG Lei;XIA Yun;WANG Zhi(Department of Oncology,Jiujiang First People's Hospital,Jiujiang 332000,Jiangxi Province,China)

机构地区：[1]九江市第一人民医院肿瘤科,江西九江332000

出　　处：《罕少疾病杂志》2024年第12期103-105,共3页Journal of Rare and Uncommon Diseases

基　　金：江西省卫生健康委科技计划项目(202211877)。

摘　　要：目的研究白蛋白碱性磷酸酶比值用于评价结直肠癌患者术后化疗预后的价值。方法通过回顾性分析法选择2020年7月至2022年12月我院纳入的结直肠癌患者100例,统计并整理其病历资料,分别测定其白蛋白、碱性磷酸酶指标,计算白蛋白碱性磷酸酶比值,对比白蛋白/碱性磷酸酶≥0.5和<0.5患者的临床资料,将有差异项代入多因素Logistic方程,分析影响化疗预后的风险因素,最后比较单一白蛋白、碱性磷酸酶和白蛋白/碱性磷酸酶的灵敏度及特异度。结果100例结直肠癌患者经检查,发现其白蛋白(40.56±3.48)g/L,碱性磷酸酶(93.17±5.68)U/L,白蛋白/碱性磷酸酶(0.48±0.15),其中白蛋白/碱性磷酸酶≥0.5有42例,<0.5有58例。A组在年龄、TNM分期、病灶位置、病灶直径、淋巴结转移、浸润深度、预后上与B组存在显著差别(P<0.05)。通过多因素Logistic分析,发现年龄、TNM分期、病灶位置、病灶直径、淋巴结转移、浸润深度、预后均是影响白蛋白/碱性磷酸酶表达的风险因素。白蛋白/碱性磷酸酶的灵敏度及特异度均较单一白蛋白、碱性磷酸酶更高。结论白蛋白碱性磷酸酶比值用于预测结直肠癌患者术后化疗预后的效果显著,灵敏度及特异度较高,值得推广。Objective To study the value of albumin alkaline phosphatase ratio to evaluate the prognosis of postoperative chemotherapy in patients with colorectal cancer.Methods 100 colorectal cancer patients included in our hospital from July 2020 to December 2022,the medical records were collected,albumin and alkaline phosphatase were determined,and the ratio of albumin alkaline phosphatase was calculated,comparing the clinical data of patients with albumin/alkaline phosphatase 0.5 and<0.5,analyzing the risk factors affecting the prognosis of chemotherapy,and finally comparing the sensitivity and specificity of single albumin,alkaline phosphatase and albumin/alkaline phosphatase.Results 100 colorectal cancer patients were found to have albumin(40.56±3.48)g/L,alkaline phosphatase(93.17±5.68)U/L,albumin/alkaline phosphatase(0.48±0.15),including 42 albumin/alkaline phosphatase 0.5 and 58<0.5.Group A was significantly different from group B in terms of age,TNM stage,lesion location,lesion diameter,lymph node metastasis,depth of invasion,and prognosis(P<0.05).By multifactorial Logistic analysis,age,TNM stage,location of lesion,lesion diameter,lymph node metastasis,depth of invasion,and prognosis were all risk factors affecting albumin/alkaline phosphatase expression.The sensitivity and specificity of albumin/alkaline phosphatase were higher than those of single albumin and alkaline phosphatase.Conclusion The ratio of albumin alkaline phosphatase to predict the prognosis of postoperative chemotherapy in colorectal cancer patients has a significant effect,with high sensitivity and specificity.

关 键 词：化疗 白蛋白 结直肠癌 碱性磷酸酶 

分 类 号：R574.63[医药卫生—消化系统]