心境稳定剂联合草酸艾司西酞普兰治疗双相情感障碍抑郁发作的效果及对神经因子、甲状腺激素水平的影响  

Effect of mood stabilizers combined with escitalopram oxalate in the treatment of depressive episodes of bipolar disorder and its influence on the levels of neurofactors and thyroid hormone

作　　者：李静 孙志强 LI Jing;SUN Zhiqiang(Zhumadian Second People's Hospitalfourth Department of psychiatry,Zhumadian 463000,China;Zhumadian Second People's HospitalDepartment of Pharmacy,Zhumadian 463000,China)

机构地区：[1]驻马店市第二人民医院精神四科,河南驻马店463000 [2]驻马店市第二人民医院药学部,河南驻马店463000

出　　处：《延边大学医学学报》2024年第4期404-407,共4页Journal of Medical Science Yanbian University

摘　　要：目的:探讨心境稳定剂联合草酸艾司西酞普兰治疗双相情感障碍抑郁发作的效果及对神经因子、甲状腺激素水平的影响。方法:选取驻马店市第二人民医院2022年1月至2024年1月收治的100例双相情感障碍抑郁发作患者,应用随机数字表法将患者分为对照组和试验组,各50例。对照组采用心境稳定剂治疗,试验组采用心境稳定剂联合草酸艾司西酞普兰治疗,对比两组患者的疗效及各项临床指标。结果:试验组治疗总有效率高于对照组(P<0.05)。治疗后,试验组胶质细胞源性神经营养因子(GDNF)、神经生长因子(NGF)、脑源性神经营养因子(BDNF)水平均高于对照组(P<0.05)。治疗后,试验组促甲状腺激素(TSH)水平高于对照组,游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT_(3))水平均低于对照组(P<0.05)。治疗后,试验组汉密尔顿抑郁量表17版本(HAMD-17)评分、负性认知加工偏向问卷(NCPBQ)评分均低于对照组(P<0.05)。结论:心境稳定剂联合草酸艾司西酞普兰治疗双相情感障碍抑郁发作疗效显著,可改善患者神经因子及甲状腺激素水平,减轻抑郁情绪及负性认知。Objective:To explore the effect of mood stabilizer combined with escitalopram oxalate in the treatment of depressive episodes of bipolar disorder and its influence on the levels of neurofactors and thyroid hormone.Method:A total of 100 patients with depressive episodes of bipolar disorder admitted to Zhumadian Second People's Hospital from January 2022 to January 2024 were selected and divided into control group and experimental group by random number table method,with 50 cases in each group.The control group was treated with mood stabilizer,and the experimental group was treated with mood stabilizer combined with escitalopram oxalate.The clinical efficacy and indexes of the two groups were compared.Result:The total effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,the levels of glial cell derived neurotrophic factor(GDNF),nerve growth factor(NGF)and brain derived neurotrophic factor(BDNF)in the experimental group were higher than those in the control group(P<0.05).After treatment,the level of thyroid stimulating hormone(TSH)in the experimental group was higher than that in the control group,and the levels of free thyroxine(FT4)and free triiodothyronine(FT_(3))in the experimental group were lower than those in the control group(P<0.05).After treatment,the scores of Hamilton Depression Scale 17(HAMD-17)and negative cognitive Processing Bias Questionnaire(NCPBQ)in the experimental group were lower than those in the control group(P<0.05).Conclusion:Mood stabilizer combined with escitalopram oxalate is effective in the treatment of depressive episodes of bipolar disorder,which can improve the levels of neurofactors and thyroid hormone,reduce depressive mood and negative cognition.

关 键 词：心境稳定剂 草酸艾司西酞普兰 双相情感障碍 抑郁发作 神经因子 甲状腺激素 

分 类 号：R749.41[医药卫生—神经病学与精神病学]