饮食干预实验模型研究进展  

Research progress on experimental models of dietary interventions

作　　者：赖金鑫 刘可容 LAI Jin-xin;LIU Ke-rong

机构地区：[1]无锡市第八人民医院,江苏无锡214011 [2]无锡市儿童医院,江苏无锡214023

出　　处：《中国疗养医学》2025年第1期92-95,共4页Chinese Journal of Convalescent Medicine

基　　金：无锡市科学与技术发展基金(K20231061)。

摘　　要：适当的饮食干预是促进健康老龄化和延长寿命的关键策略,旨在通过科学的饮食调整,开发精确的营养疗法来减缓与年龄相关的生理衰退,并为治疗多种慢性疾病提供新的思路。尽管个体间在遗传、生活方式以及对营养需求上存在显著差异,为实现个性化营养干预带来了挑战性,但同样为深入研究提供了广阔的空间。本研究综合分析了目前广泛用于改善健康和治疗疾病不同形式的饮食干预模型,包括禁食、热量限制饮食、脂质相关饮食、蛋白质限制饮食、微量元素干预饮食和代谢物干预饮食模型。本综述为临床前研究选择合适的饮食干预方案提供了思路和参考,帮助研究者根据实验目的和个体差异,选择最合适的饮食干预策略,以期达到预防疾病、促进健康和提高生活质量的目标。通过这一研究,我们期望为推动营养科学的进步和实现健康老龄化做出积极贡献。Appropriate dietary interventions are pivotal in fostering healthy aging and extending lifespan.The goal is to refine nutritional therapies that mitigate age-related physiological deterioration through evidence-based dietary adjustments.Despite the considerable variability in individual genetics,lifestyles,and nutritional requirements that challenge the implementation of personalized nutrition plans,these differences also present rich opportunities for comprehensive research.This review conducted a comprehensive synthesis of prevalent dietary intervention paradigms,which were extensively utilized to enhance health and combat illness.The experimental models of dietary interventions included fasting,calorie restriction,lipid-focused diets,protein limitation,micronutrient supplementation,and metabolite-targeted diets.This study provided a valuable resource for selecting suitable dietary interventions in preclinical research,guiding researchers in tailoring the most fitting strategies based on experimental objectives and individual profiles.The aim is to optimize outcomes in disease prevention,health enhancement,and the improvement of life quality.We look forward to making a positive contribution to the advancement of nutritional science and the achievement of healthy aging.

关 键 词：饮食干预 实验模型 热量限制 

分 类 号：R151[医药卫生—营养与食品卫生学]