急性脑梗死患者Trevo支架取栓术后转归影响因素及血清PTX3、IMA水平变化分析  

Analysis of the influencing factors of postoperative outcomes and changes of serum PTX3 and IMA levels in patients with acute cerebral infarction after Trevo stent thrombectomy

作　　者：周伟锋 柴红杰 周永生 ZHOU Wei-feng;CHAI Hong-jie;ZHOU Yong-sheng

机构地区：[1]许昌医院神经内科,河南许昌461000

出　　处：《中国疗养医学》2025年第1期105-108,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的分析急性脑梗死(acutecerebralinfarction,ACI)患者Trevo支架取栓术后转归影响因素及血清正五聚体蛋白(PTX3)、缺血修饰白蛋白(IMA)水平变化。方法选取2020年11月至2023年11月在许昌医院行Trevo支架取栓治疗的150例ACI患者为研究对象,根据患者术后恢复情况分为预后优良组93例,预后不良组57例。比较两组一般资料及治疗前后血清PTX3、IMA水平,分析影响术后转归的因素及联合诊断预后转归的预测价值。结果两组年龄、发病至入院时间、梗死部位、收缩压连续变异性方面比较,差异具有统计学意义(P<0.05);治疗后预后优良组血清PTX3、IMA水平低于预后不良组(P<0.05);年龄、发病至入院时间、收缩压连续变异性为影响预后转归的不良因素(P<0.05);梗死部位为影响预后转归的保护因素(P<0.05);血清PTX3、IMA水平联合诊断ACI患者Trevo支架取栓术后恢复情况的AUC为0.913。结论ACI患者Trevo支架取栓术后转归与年龄、发病至入院时间、梗死部位、收缩压连续变异性密切相关,监测治疗前后血清PTX3、IMA水平可作为临床评估患者预后恢复情况的参考指标。Objective To analyze the influencing factors and changes in serum levels of pentamer protein(PTX3)and ischemia modified albumin(IMA)in patients with acute cerebral infarction(ACI)after Trevo stent thrombectomy.Methods 150 ACI patients who underwent Trevo stent thrombectomy treatment at Xuchang Hospital from November 2020 to November 2023 were selected as the study subjects.According to their postoperative recovery,the patients were divided into a good prognosis group of 93 cases and a poor prognosis group of 57 cases.The general information and serum PTX3 and IMA levels before and after treatment between two groups were compared,the factors affecting postoperative outcomes were analyzed,and the predictive value of combined diagnosis for prognosis was evaluated.Results There were statistically significant differences(P<0.05)between the two groups in terms of age,time from onset to admission,location of infarction,and continuous variability of systolic blood pressure;The serum levels of PTX3 and IMA in the group with good prognosis after treatment were lower than those in the group with poor prognosis(P<0.05);Age,time from onset to admission,and continuous variability of systolic blood pressure were adverse factors affecting prognosis(P<0.05);The location of infarction was a protective factor affecting prognosis(P<0.05);The AUC of the combined diagnosis of serum PTX3 and IMA levels for recovery after Trevo stent thrombectomy in ACI patients was 0.913.Conclusion The postoperative outcome of Trevo stent thrombectomy in ACI patients is closely related to age,time from onset to admission,location of infarction,and continuous variability of systolic blood pressure.Monitoring serum PTX3 and IMA levels before and after treatment can serve as reference indicators for clinical evaluation of patient prognosis and recovery.

关 键 词：正五聚体蛋白 缺血修饰白蛋白 急性脑梗死 术后转归 Trevo支架取栓术 

分 类 号：R743.33[医药卫生—神经病学与精神病学]