异甘草酸镁注射液致过敏性休克1例分析  

One Case of Anaphylaxis Caused by Magnesium Isoglycyrrhizinate Injection

作　　者：江楠[1] 王琨 张钢平 邢瑞敏[1] 王海叶[1] JIANG Nan;WANG Kun;ZHANG Gangping;XING Ruimin;WANG Haiye(Department of Pharmacy,Handan Central Hospital,Handan Hebei 056002,China;Pharmacovigilance Center of Hebei,Shijiazhuang Hebei 050000,China;Drug Monitoring Center of Handan,Handan Hebei 056002,China)

机构地区：[1]邯郸市中心医院药学部,河北邯郸056002 [2]河北省药物警戒中心,河北石家庄050000 [3]邯郸市药品监测中心,河北邯郸056002

出　　处：《中国药物警戒》2024年第11期1309-1311,共3页Chinese Journal of Pharmacovigilance

基　　金：河北省邯郸市科技计划项目(21422083130)。

摘　　要：目的探讨1例异甘草酸镁注射液诱发过敏性休克的病因和特征,为临床安全合理用药提供参考。方法分析本院发生的1例异甘草酸镁注射液静脉滴注致过敏性休克病例,文献回顾异甘草酸镁注射液常见不良反应及其致过敏性休克的发病机制。结果结合患者临床表现和用药时间的相关性,认为异甘草酸镁注射液引起过敏性休克不良反应的关联性为很可能,经过积极抗过敏治疗和对症支持治疗,过敏性休克症状逐渐减轻并好转。结论在使用异甘草酸镁注射液时,应注意其不良反应风险,提高对严重过敏反应的认识,尤其是对有过敏史的患者,要提前准备好应对过敏性休克的措施。Objective To analyze the etiology and characteristics of anaphylaxis induced by magnesium isoglycyrrhizinate injection so as to provide references for clinical safe use.Methods One case of anaphylaxis caused by intravenous drip of magnesium isoglycyrrhizinate injection was analyzed.The adverse reactions of magnesium isoglycyrrhizinate injection and the pathogenesis of anaphylaxis were reviewed.Results The chances of anaphylaxis being induced by magnesium isoglycyrrhizinate injection were considered high.After active anti-allergic therapy and symptomatic support therapy,the symptoms of anaphylaxis gradually subsided and improved.Conclusion When magnesium isoglycyrrhizinate injection is used,clinicians ought to be alert to the risk of adverse reactions and severe allergic reactions,especially among patients with a history of allergy,and be ready to take precautions.

关 键 词：异甘草酸镁 注射液 过敏性休克 药物警戒 药品不良反应 

分 类 号：R975[医药卫生—药品] R994.11[医药卫生—药学]