MR-PWI及DTI在胶质母细胞瘤诊断中的应用  

Application of MR-PWI and DTI in the diagnosis of glioblastoma

作　　者：龙丹丹 汤敏 吴浛嘉 LONG Dandan;TANG Min;WU Hanjia(Mianyang Hospital,School of Medicine UESTC/Mianyang Central Hospital,Mianyang 621000,China)

机构地区：[1]电子科技大学医学院附属绵阳医院,绵阳市中心医院,四川绵阳621000

出　　处：《中国实用神经疾病杂志》2025年第1期13-17,共5页Chinese Journal of Practical Nervous Diseases

基　　金：绵阳市麻醉与神经调控重点实验室开放课题资助项目(编号:MZSJ202308)。

摘　　要：目的探讨磁共振灌注加权成像(MR-PWI)及扩散张量成像(DTI)在胶质母细胞瘤诊断中的应用价值。方法选取2021-01—2023-01绵阳市中心医院收治的80例胶质母细胞瘤患者为研究对象,所有患者均行MR-PWI和DTI扫描,根据胶质母细胞瘤术后是否复发分为复发组和未复发组,比较2组患者的MR-PWI扫描参数[脑血容量(CBV)比值、脑血流量(CBF)比值、平均通过时间(MTT)比值、达峰时间(TTP)比值]、DTI扫描参数[各向异性分数(FA)最大值、FA平均值、FA最小值],采用受试者工作特征(ROC)曲线分析MR-PWI及DTI对胶质母细胞瘤的诊断价值。结果复发组CBV、CBF比值高于未复发组(t=5.454、4.404,P<0.05)。2组MTT、TTP比较,差异无统计学意义(P>0.05)。ROC曲线显示,CBV联合CBF诊断胶质母细胞瘤术后复发的AUC为0.888,高于CBV的0.818、CBF的0.778(Z=2.255、2.484,P<0.05)。复发组FA最大值、FA平均值低于未复发组(t=5.033、3.894,P<0.05)。2组FA最小值比较,差异无统计学意义(P>0.05)。ROC曲线显示,FA最大值联合FA平均值诊断胶质母细胞瘤术后复发的AUC为0.831,高于FA最大值的0.793及FA平均值的0.737。结论MR-PWI、DTI扫描有助于诊断胶质母细胞瘤术后复发。Objective To investigate the application value of magnetic resonance perfusion weighted imaging(MR-PWI)and diffusion tensor imaging(DTI)in the diagnosis of glioblastoma.Methods A total of 80 patients with glioblastoma in the Mianyang Central Hospital between January 2021 and January 2023 were enrolled as the research objects.All the patients underwent MR-PWI and DTI scans.According to presence or absence of postoperative recurrence of glioblastoma,they were divided into recurrence group and non-recurrence group.MR-PWI scan parameters(cerebral blood volume(CBV)ratio,cerebral blood flow(CBF)ratio,mean transit time(MTT)ratio,time to peak(TTP)ratio)and DTI scan parameters(maximum value of fractional anisotropy(FA),mean value of FA,the minimum value of FA)were compared between the two groups.The diagnostic value of MR-PWI and DTI for glioblastoma was analyzed by receiver operating characteristic(ROC)curve.Results The ratios of CBV and CBF in recurrence group were higher than those in non-recurrence group(t=5.454,4.404,P<0.05).There was no significant difference in MTT or TTP between the two groups(P>0.05).ROC curves analysis showed that AUC of CBV combined with CBF in the diagnosis of glioblastoma recurrence was 0.888,which was greater than that of CBV and CBF alone(0.818,0.778,respectively;Z=2.255,2.484,P<0.05).The maximum value and mean value of FA in recurrence group were lower than those in non-recurrence group(t=5.033,3.894,P<0.05),but there was no significant difference in the minimum value of FA between the two groups(P>0.05).ROC curves analysis showed that AUC of the maximum FA combined with the mean FA in the diagnosis of postoperative recurrence of glioblastoma was 0.831,which was greater than the maximum FA and the mean FA(0.793,0.737,respectively).Conclusion MR-PWI and DTI scans are beneficial to diagnose postoperative recurrence of glioblastoma.

关 键 词：胶质母细胞瘤 磁共振灌注加权成像 磁共振扩散张量成像 复发 诊断价值 

分 类 号：R739.41[医药卫生—肿瘤]