基于Solitaire AB支架的血管内治疗大动脉闭塞急性轻型缺血性脑卒中患者的疗效观察  

Observation of the effect of endovascular therapy based on Solitaire AB stent in the treatment of acute mild ischemic stroke with large artery occlusion

作　　者：孙洋子 伍贞宇 游咏 曾超胜 王德生[1] 刘胜锋 龙发青[1] SUN Yangzi;WU Zhenyu;YOU Yong;ZENG Chaosheng;WANG Desheng;LIU Shengfeng;LONG Faqing(The Second Affiliated Hospital of Hainan Medical College,Haikou 570000,China)

机构地区：[1]海南医学院第二附属医院,海南海口570000

出　　处：《中国实用神经疾病杂志》2025年第1期53-57,共5页Chinese Journal of Practical Nervous Diseases

基　　金：海南省卫生健康委员会科研课题项目(编号:21A200268)。

摘　　要：目的观察基于Solitaire AB支架的血管内治疗大动脉闭塞急性轻型缺血性脑卒中(MIS)患者的效果。方法回顾性分析2021-01—2022-05海南医学院第二附属医院收治的108例大动脉闭塞急性MIS患者的临床资料,观察组56例,对照组52例。对照组患者接受药物治疗,观察组患者接受基于Solitaire AB支架的EVT治疗,所有患者均随访3个月,比较2组患者的疗效、血管再通率、不良反应及治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分、日常生活活动能力(ADL)评分。结果观察组总有效率及血管再通率均优于对照组(P<0.05)。2组治疗前NIHSS、m RS、ADL评分比较差异均无统计学意义(P>0.05),2组治疗后NIHSS、mRS评分均低于治疗前,观察组低于对照组(P<0.05);ADL评分均高于治疗前,观察组高于对照组(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论基于Solitaire AB支架的EVT治疗大动脉闭塞急性MIS的疗效优于单纯药物治疗,且能明显改善患者神经功能、日常生活能力及短期预后,同时不会明显增加不良反应发生率,值得临床应用。Objective To observe the effect of endovascular therapy(EVT)based on Solitaire AB stent in the treatment of acute mild ischemic stroke(MIS)with large artery occlusion.Methods The clinical data of 108 patients with acute MIS with large artery occlusion admitted to the Second Affiliated Hospital of Hainan Medical College from January 2021 to May 2022 were retrospectively analyzed.They were divided into the observation group(56 cases)and the control group(52 cases).The patients in the control group received medication and patients in the observation group received EVT based on the Solitaire AB stent.The patients in both groups were followed up for 3 months.The efficacy,vascular recanalization rate,adverse reactions,NIHSS score,modified Rankin scale(mRS)score,and activities of daily living(ADL)scores of the patients in the two groups were compared before and after treatment.Results The total effective rate and vascular recanalization rate in the observation group were significantly better than those in the control group(P<0.05).Before treatment,there was no difference in NIHSS,mRS and ADL scores between the two groups(P>0.05).After treatment,the scores of NIHSS and mRS in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The ADL score was higher in the observation group than that in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The therapeutic effect of EVT based on Solitaire AB stent in the treatment of acute MIS with large artery occlusion is better than that of drug therapy alone,it can significantly improve the neurological function,daily living ability and short-term prognosis,and does not significantly increase the incidence of adverse reactions,which is worthy of clinical application.

关 键 词：急性轻型缺血性脑卒中 大动脉闭塞 血管内治疗 Solitaire AB支架 药物治疗 日常生活活动能力 

分 类 号：R743.3[医药卫生—神经病学与精神病学]