升阳益胃汤加味联合PPI治疗慢性萎缩性胃炎患者临床疗效及治疗前后胃镜组织学的影响  

Clinical efficacy of Shengyang Yiwei Decoction combined with PPI in the treatment of chronic atrophic gastritis and the influence of gastroscopy histology before and after treatment

作　　者：董一 李媛媛 崔红霞 DONG Yi;LI Yuanyuan;CUI Hongxia(Department of Traditional Chinese Medicine,Jiaozhou Central Hospital,Qingdao Shandong 266300,China;Department of Gastroenterology,Jiaozhou Central Hospital,Qingdao Shandong 266300,China)

机构地区：[1]青岛市胶州中心医院中医科,山东青岛266300 [2]青岛市胶州中心医院消化内科,山东青岛266300

出　　处：《四川中医》2024年第12期78-80,共3页Journal of Sichuan of Traditional Chinese Medicine

基　　金：2022年度青岛市中医药科技项目(编号:2022-zyym22)。

摘　　要：目的:探究升阳益胃汤加味联合质子泵抑制药(PPI)治疗慢性萎缩性胃炎患者临床疗效及治疗前后胃镜组织学的影响。方法:选取2022年8月~2023年7月120例于青岛市胶州中心医院中医门诊、消化内科门诊进行就诊的慢性萎缩性胃炎患者作为研究对象,采用随机数字表法将其分为研究组和对照组,各60例。对照组采用常规PPI疗法,研究组在对照组的基础上增加升阳益胃汤加味治疗。比较两组的疗效、治疗前后胃黏膜病变程度、治疗前后的中医证候积分和胃镜病理评分,并记录不良反应的发生情况。结果:研究组的总有效率为91.67%,高于对照组的78.33%,两组的总有效率进行比较,差异有统计学意义(P<0.05)。治疗后,两组的IL-6、TNF-α、IL-1β水平均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗后两组的胃镜组织情况进行比较,差异有统计学意义(P<0.05)。治疗后两组的胀满、胃痛、痛处拒按、黑便、面色暗滞、总分均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05)。结论:升阳益胃汤加味联合PPI治疗慢性萎缩性胃炎具有较高的疗效,可以有效改善患者的胃黏膜病变程度和中医证候积分,降低患者血清炎症因子水平,具有一定的临床应用价值。Objective:To explore the clinical efficacy of Shengyang Yiwei Decoction combined with proton pump inhibitor(PPI)in the treatment of chronic atrophic gastritis and the influence of gastroscopy histology before and after treatment.Methods:From August 2022to July 2023,120patients with chronic atrophic gastritis who were treated in the traditional Chinese medicine(TCM)outpatient department and gastroenterology outpatient department of Jiaozhou Central Hospital of Qingdao were selected as the research objects,and were divided into study group and control group by random number table method,with 60cases in each group.The control group was treated with conventional PPI therapy,and the study group was treated with Shengyang Yiwei Decoction on the basis of the control group.The efficacy,the degree of gastric mucosal lesion before and after treatment,TCM syndrome score and gastroscopy pathological score before and after treatment were compared between the two groups,and the occurrence of adverse reactions was recorded.Results:The total effective rate of the study group was 91.67%,which was higher than that of the control group(78.33%).The difference between the two groups was statistically significant(P<0.05).After treatment,the levels of IL-6,TNF-αand IL-1βin two groups were lower than before treatment,and the levels in study group were lower than those in control group,with statistical significance(P<0.05).After treatment,the gastroscopy tissue of the two groups was compared,and the difference was statistically significant(P<0.05).After treatment,the total scores of distension,stomachache,pain rejection,black stool,dark and stagnant face in two groups were lower than before treatment,and the study group was lower than the control group,the differences were statistically significant(P<0.05).Conclusion:Shengyang Yiwei Decoction combined with PPI has a high effect in the treatment of chronic atrophic gastritis,which can effectively improve the degree of gastric mucosal lesions and TCM syndrome scores,and reduce the level

关 键 词：升阳益胃汤加味 质子泵抑制药 慢性萎缩性胃炎 临床疗效 胃镜组织学 

分 类 号：R573.32[医药卫生—消化系统]