脑小血管病认知障碍的治疗及研究  

Study of the treatment for cognitive impairment in cerebral small vessel disease

作　　者：王利军[1] 牛延良[1] WANG Lijun;NIU Yanliang(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第五附属医院,河南郑州450052

出　　处：《中国实用神经疾病杂志》2024年第12期1553-1556,共4页Chinese Journal of Practical Nervous Diseases

基　　金：河南省科技攻关项目(编号:222102310197)。

摘　　要：目的探讨高频重复经颅磁刺激(HF-rTMS)治疗脑小血管病(CSVD)认知障碍的疗效。方法选取113例影像学表现为脑白质高信号的慢性脑小血管病所致认知障碍的患者,分为HF-rTMS治疗组和对照组,HF-rTMS治疗组在常规治疗基础上予以10 Hz的高频重复经颅磁刺激治疗,对照组予以常规治疗,分别比较2组患者治疗前后MoCA量表总分、各子项评分和Barthel指数评定量表(BI)评分。结果治疗后HF-rTMS治疗组MoCA评分22.14±2.56,高于对照组的20.65±1.90,差异有统计学意义(P<0.05);HF-rTMS治疗组视空间与执行功能、计算、记忆3项评分分别为3.55±0.94、2.36±0.55、3.24±0.90,高于对照组的3.09±1.01、2.11±0.69、2.82±0.84,组间比较差异均有统计学意义(P<0.05)。治疗后HF-r TMS治疗组BI评分84.74±12.99,高于对照组的79.91±11.92,差异有统计学意义(P<0.05)。结论HF-r TMS对慢性CSVD患者的认知障碍有一定疗效,能够改善脑小血管病患者的视空间与执行功能、计算力及记忆力,提高其日常生活能力。Objective To investigate the efficacy of HF-rTMS in the treatment of cognitive impairment in cerebral small vessel disease(CSVD).Methods A total of 113 patients with cognitive impairment caused by chronic CSVD with white matter hyperintensites on imaging were selected.These patients were divided into the HF-rTMS treatment group and the control group.The HF-rTMS treatment group was treated by 10 Hz high-frequency repetitive transcranial magnetic stimulation on the basis of conventional treatment,and the control group was treated with conventional treatment.The scores of MoCA scale and the Barthel index(BI)assessment scale before and after treatment between the two groups were compared.Results After treatment,MoCA score of the HF-rTMS treatment group was 22.14±2.56,which was higher than 20.65±1.90 of the control group,with a statistical difference(P<0.05).The scores of HF-rTMS treatment group in visuospatial and executive function,calculation,and memory were 3.55±0.94,2.36±0.55,3.24±0.90,respectively,which were higher than those of the control group(3.09±1.01,2.11±0.69,2.82±0.84,respectively),with statistical differences(P<0.05).The BI score of the HF-rTMS treatment group was 84.74±12.99,which was higher than 79.91±11.92 of the control group,with statistical difference(P<0.05).Conclusion HF-rTMS has a certain effect on cognitive impairment in patients with chronic CSVD,which can improve visuospatial and executive function,calculation ability and memory,and enhance the activity of daily living of patients.

关 键 词：脑小血管病 认知障碍 高频重复经颅磁刺激 视空间与执行功能 计算力 记忆力 日常生活能力 

分 类 号：R743.9[医药卫生—神经病学与精神病学]