Co-assembled C13-dipeptide hydrogels by Gallic Acid (CA) and epigallocatechin gallate (EGCG) with antibacterial activity  

作　　者：Tan Hu Siyi Pan 

机构地区：[1]College of Food Science and Technology,Huazhong Agricultural University,No.1 Shizishan Road,Wuhan,Hubei,430070,PR China [2]Key Laboratory of Environment Correlative Dietology(Huazhong Agricultural University),Ministry of Education,China [3]Hubei Key Laboratory of Fruit&Vegetable Processing&Quality Control(Huazhong Agricultural University),Wuhan,Hubei,430070,PR China

出　　处：《Food Bioscience》2022年第5期933-940,共8页食品生物科学（英文）

基　　金：supported by China Agriculture Research System of MOF and MARA(CARS-26-07B);Fundamental Research Funds for the Central Universities(2662019PY016,2662020SPPY011);Hubei Province Technology Innovation Special Major Project(2018ABA072).

摘　　要：The self-assembled peptide-based hydrogels have been widely utilized in foods.However,the self-assembled hydrogels still have some shortages such as low mechanical properties and hydrogel stabilities.Herein,we designed two co-assembled C_(13)-WS hydrogels conjugated by Gallic Acid(CA)and Epigallocatechin Gallate(EGCG).The introduction of CA and EGCG into C_(13)-WS hydrogels can significantly improve the mechanical properties and hydrogel stabilities.The storage modulus(G’)values of co-assembled C_(13)-WS/CA and C_(13)-WS/EGCG were 13.33 KPa and 16 KPa,respectively.From transmission electron microscope(TEM)results,CA and EGCG contributed to the rearrangement of C_(13)-WS molecules during co-assembly.Moreover,the self-/co-assembled C_(13)-WS hydrogels showed antimicrobial activity against E.coli,P.aeruginosa,and S.epidermidis.The introduction of CA and EGCG significantly enhanced the antibacterial activity of C_(13)-WS hydrogels.Our findings provide a novel strategy for the development of stable supramolecular antibacterial short peptide hydrogels through co-assembly.

关 键 词：Peptide hydrogels C_(13)-dipeptides Co-assembly Antibacterial activity 

分 类 号：TS201[轻工技术与工程—食品科学]