Study of the anti-fatigue properties of macamide,a key component in maca water extract,through foodomics and gut microbial genomics  

作　　者：Chang Liu Hanyi Hua Hongkang Zhu Wenqian Xu Yahui Guo Weirong Yao He Qian Yuliang Cheng 

机构地区：[1]State Key Laboratory of Food Science and Technology,Jiangnan University,No.1800 Lihu Avenue,Wuxi,Jiangsu Province,214122,China [2]School of Food Science and Technology,Jiangnan University,No.1800 Lihu Avenue,Wuxi,Jiangsu Province,214122,China [3]Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,Jiangnan University,No.1800 Lihu Avenue,Wuxi,Jiangsu Province,214122,China

出　　处：《Food Bioscience》2022年第5期1265-1275,共11页食品生物科学（英文）

基　　金：supported by the National Key Research and Development Program of China(Nos.2020YFC1606800).

摘　　要：Lepidium meyenii Walp.is a type of food used to fight fatigue,and macamides is the key anti-fatigue component in Lepidium meyenii Walp.water extract(Maca).The mechanisms of action of several foods with anti-fatigue properties lie in the oxidative balance of tissues;however,little attention has been given to the microbiome.The gut microbial community is closely related to dietary choices,as well as exercise-induced skeletal muscle fatigue.As such,this study used a foodomics approach to analyze the anti-fatigue properties of maca amide,a key component in maca,on the gut microbiome.The key components in maca were identified,and after validation in a mouse model,an analysis of the gut microbiome was performed.The results of database searches and network analyses showed that the key anti-fatigue component of maca was N-benzyl-9Z,12Z-octadecadienamide(Mm).Further analyses revealed that the key microbes metabolizing Mm belonged to Alistipes,Alloprevotella,Parabacteroides,and Butyricimonas genera and the Prevotellaceae in mice.The results of microbial analysis showed that Mm could improve exercise-induced skeletal muscle fatigue in mice by modulating the L-glutamate-ornithine-proline axis through the breakdown of histidine,arginine,and proline.Therefore,from foodomics and gut microbial genomics perspectives,this study demonstrates that macamide is the key anti-fatigue component in maca,and these findings provide new insights for the development of foods that fight fatigue.

关 键 词：MACA N-Benzyl-9Z 12Z-octadecadienamide Foodmics Gut microbial genomics ANTI-FATIGUE 

分 类 号：TS201.3[轻工技术与工程—食品科学]