酰基辅酶A结合结构域蛋白3生理功能研究进展  

Research Progress on the Physiological Function of ACBD3

作　　者：张新宇 彭俊[1,2,3] 亓明月 刘洋 郭慧 ZHANG Xin-Yu;PENG Jun;QI Ming-Yue;LIU Yang;GUO Hui(The First People's Hospital of Yunnan Province;The Affiliated Hospital of Kunming University of Science and Technology;School of Medicine,Kunming University of Science and Technology,Kunming 650032,China)

机构地区：[1]云南省第一人民医院 [2]昆明理工大学附属医院 [3]昆明理工大学医学院,昆明650032

出　　处：《生理科学进展》2024年第6期553-559,共7页Progress in Physiological Sciences

基　　金：国家自然科学基金(82103049);云南省科学技术厅基础研究专项(202201AU070015,202201AS070009);云南省科学技术厅昆明医科大学联合专项面上项目(202201AY070001-233);云南省高层次人才青年拔尖人才项目(KH-SWR-QNBJ-2020-002)资助课题。

摘　　要：酰基辅酶A结合结构域蛋白3(acyl-coenzyme A binding domain containing 3,ACBD3)是一种高尔基体支架蛋白,参与多种蛋白质-蛋白质相互作用,在细胞功能和信号传导中发挥广泛生物学作用。ACBD3参与线粒体胆固醇运输和类固醇合成,调控病原微生物复制、细胞凋亡和神经发生等过程,并在肿瘤和亨廷顿舞蹈病等疾病的发生发展中具有重要作用。本文对ACBD3的结构特征及其生理功能的研究进展进行综述。Acyl-coenzyme A binding domain containing 3(ACBD3)is a scaffold protein of the Golgi apparatus that participates in various protein-protein interactions.ACBD3 plays a wide range of biological roles in cellular function and signal transduction.It is involved in mitochondrial cholesterol transport and steroid synthesis,regulating processes such as pathogen replication,cell apoptosis,and neurogenesis.Furthermore,ACBD3 plays crucial roles in the occurrence and development of diseases,such as tumors and Huntington's disease.In this article,we review the research progress on the structural characteristics and physiological functions of ACBD3.

关 键 词：酰基辅酶A结合结构域蛋白3 高尔基体 病原微生物复制 肿瘤发生 

分 类 号：R363[医药卫生—病理学]