TRPV4通道在正畸牙齿移动中的研究进展  

Research Progress on TRPV4 Channel in Orthodontic Tooth Movement.

作　　者：苏轩辰 刘亚丽[1,2,3] SU Xuanchen;LIU Yali(School of Stomatology,Kunming Medical University,Kunming 650106,China;Yunnan Key Laboratory of Stomatology,Kunming 650106,China;Department of Orthodontics,Stomatological Hospital Affiliated to Kunming Medical University,Kunming 650106,China.)

机构地区：[1]昆明医科大学口腔医学院,云南昆明650106 [2]云南省口腔医学重点实验室,云南昆明650106 [3]昆明医科大学附属口腔医院正畸科,云南昆明650106

出　　处：《口腔医学研究》2024年第12期1049-1053,共5页Journal of Oral Science Research

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项重点项目(编号:202301AY070001-010);国家级大学生创新创业训练计划资助项目(编号:202310678040)。

摘　　要：正畸牙齿移动是临床正畸治疗的关键环节,通过在牙齿上施加合适的正畸力,正畸力传递至牙周会引起牙齿周围软硬组织的适应性改建。瞬时受体电位香草素受体4型通道蛋白(transient receptor potential vanilloid 4 channel,TRPV4)是一个作用繁多、机制复杂的机械敏感性钙离子通道蛋白,在调控机械力的传导、炎症反应等方面都发挥着重要的作用,近年来陆续有研究者发现TRPV4通道也参与了正畸牙齿移动。本文就TRPV4通道在正畸牙齿移动中发挥的作用作一综述,以期为临床正畸治疗提供理论依据。Orthodontic tooth movement is a key step in clinical orthodontic treatment.By applying appropriate orthodontic forces to the teeth,these forces are transmitted to the periodontium,causing adaptive remodeling of the surrounding soft and hard tissues.The transient receptor potential vanilloid 4 channel(TRPV4)is a mechanically sensitive calcium channel protein with multiple functions and complex mechanisms.It plays an important role in the transmission of mechanical forces,inflammatory responses,and other aspects.In recent years,researchers have found that the TRPV4 channel is also involved in orthodontic tooth movement.This article provides a review of the role of the TRPV4 channel in orthodontic tooth movement,aiming to provide a foundation and theoretical basis for clinical orthodontic treatment of tooth movement.

关 键 词：瞬时受体电位香草素受体4型通道蛋白 正畸牙齿移动 骨重塑 牙周组织重塑 

分 类 号：R783.5[医药卫生—口腔医学]