阿替利珠和贝伐珠单抗诱发口腔苔藓样药物反应及牙龈出血1例  

Oral Lichenoid Drug Reactions and Gingival Bleeding Induced by Atezolizumab and Bevacizumab:A Case Report.

作　　者：李佳琪 李鑫磊 周刚[1] LI Jiaqi;LI Xinlei;ZHOU Gang(State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,Key Laboratory of Oral Biomedicine Ministry of Education,Hubei Key Laboratory of Stomatology,Department of Oral Medicine,School and Hospital of Stomatology,Wuhan University,Wuhan 430079,China.)

机构地区：[1]口颌系统重建与再生全国重点实验室,口腔生物医学教育部重点实验室,口腔医学湖北省重点实验室,武汉大学口腔医(学)院口腔黏膜科,湖北武汉430079

出　　处：《口腔医学研究》2024年第12期1121-1124,共4页Journal of Oral Science Research

摘　　要：口腔苔藓样药物反应(oral lichenoid drug reactions,OLDR)是指过敏体质者使用特定药物后引起口腔黏膜苔藓样表现的疾病。诱发OLDR的药物种类繁多,由免疫治疗诱发的口腔苔藓样药物反应临床上报道较少。本文报道了1例由阿替利珠和贝伐珠单抗联合抗癌治疗诱发的口腔苔藓样药物反应及牙龈出血,探讨该疾病的临床特点及诊治原则,以期为临床上此类疾病的诊疗提供参考。Oral lichenoid drug reactions(OLDR)refer to lichenoid manifestation of the oral mucosa induced by specific drugs in individuals with allergic predispositions.There are numerous types of drugs that can trigger OLDR,but reports on oral lichenoid drug reactions induced by immunotherapy are rare.This manuscript reports a case of OLDR and gingival bleeding induced by atezolizumab and bevacizumab combination anticancer therapy,and explores its clinical features,as well as the diagnostic and treatment approaches.The aim of this case is to provide valuable insights for the clinical management of this disease.

关 键 词：口腔苔藓样药物反应 阿替利珠单抗 贝伐珠单抗 免疫相关不良事件 

分 类 号：R781.5[医药卫生—口腔医学]