B7-H3在恶性肿瘤中的作用  

Roles of B7-H3 in malignant tumors

作　　者：李苗 封祖希 李莉娟[2] 张连生[2] LI Miao;FENG Zuxi;LI Lijuan;ZHANG Liansheng(Department of Hematology,the Second Hospital of Lanzhou University,Lanzhou 730030,China;The Second Clinical Medical College of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院血液内科,兰州730030 [2]兰州大学第二临床医学院,兰州730030

出　　处：《生命的化学》2024年第12期2199-2207,共9页Chemistry of Life

基　　金：国家自然科学基金项目(82360029);国家血液系统疾病临床医学研究中心委托课题(2021WWA01);甘肃省科技计划临床医学研究中心建设项目(21JR7RA435);甘肃省科技计划自然科学基金项目(21JR7RA394,21JR11RA104)。

摘　　要：B7-H3是近年来发现的新的免疫检查点,在固有性和适应性免疫细胞以及多种肿瘤组织中异常表达。它不仅具有调节免疫系统的功能,而且能够利用非免疫学因素促进肿瘤细胞增殖、迁移以及耐药。本文介绍了B7-H3的结构和功能、在不同癌症类型中的表达水平以及在肿瘤微环境(tumor microenvironment,TME)中通过与不同的免疫细胞和信号通路互作促进肿瘤生长和免疫逃逸的机制。此外,本文还综述了B7-H3在促进肿瘤细胞代谢、耐药、侵袭等进程中的作用机制,并简述了靶向B7-H3的多种免疫治疗策略,包括单克隆抗体、联合疗法和CAR-T细胞等疗法及其在临床前模型和临床试验中的应用。本文指出,尽管B7-H3的多种作用已被揭示,但具体的受体和信号传导机制仍然不明确,需要更多研究来阐明其在癌症治疗中的确切角色,为靶向B7-H3药物的研究提供参考依据。B7-H3,a newly discovered immune checkpoint in recent years,is aberrantly expressed in both innate and adaptive immune cells as well as various tumor tissues.It not only regulates the immune system but also promotes tumor cell proliferation,migration,and drug resistance through non-immunological factors.This work introduces the structure and function of B7-H3,its expression levels in different types of cancer,and the mechanisms by which it promotes tumor growth and immune evasion in the tumor microenvironment(TME)through interactions with various immune cells and signaling pathways.Additionally,we review the role of B7-H3 in facilitating processes such as tumor cell metabolism,drug resistance,and invasion.Finally,we briefly discusse various immunotherapy strategies targeting B7-H3,including monoclonal antibodies,combination therapies,and CAR-T cell therapies,as well as their applications in preclinical models and clinical trials.It is pointed out that although many functions of B7-H3 have been revealed,its specific receptors and signaling mechanisms remain unclear,necessitating further research to elucidate its precise role in cancer treatment,aiming to provide a reference for the study of targeted B7-H3 drugs.

关 键 词：B7-H3 癌症 免疫 糖代谢 迁移 耐药 

分 类 号：R730.2[医药卫生—肿瘤]