转录因子与circRNAs在癌症中的机制及治疗前景  

Mechanisms and therapeutic prospects of transcription factors and circular RNAs in cancer

作　　者：雷潇 郑粤鑫 杨志雄 苏文媚 LEI Xiao;ZHENG Yuexin;YANG Zhixiong;SU Wenmei(First Clinical Medical School,Guangdong Medical University,Zhanjiang 524001,China;Lung Cancer Specialty,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China;Key Laboratory of Tumor Microenvironment and Organoid Research,Zhanjiang 524001,China)

机构地区：[1]广东医科大学第一临床医学院,湛江524001 [2]广东医科大学附属医院肺部肿瘤专科,湛江524001 [3]湛江市肿瘤微环境与类器官研究重点实验室,湛江524001

出　　处：《生命的化学》2024年第12期2273-2285,共13页Chemistry of Life

基　　金：国家自然科学基金项目(82073388);广东省杰出青年基金项目(2022B1515020090)。

摘　　要：在恶性肿瘤生物学进程中转录因子与环状RNA(circular RNAs,circRNAs)扮演着不可或缺的角色,其分子作用机制揭示了复杂的基因调控网络,分别在消化、生殖、泌尿、呼吸、神经和骨骼系统等多种类型的癌症中异常表达。有些转录因子能直接与circRNAs结合影响癌症的发生发展,circRNAs招募转录因子并与某些特定基因的启动子区或其他区域结合,调节基因的转录活性使其发生一系列生物学过程,这为未来癌症的诊断、预后和治疗提供了新的研究方向。然而,关于这些机制的研究仍处于不成熟阶段,特别是在治疗及临床应用方面,尚需更多探索和验证。本文将通过以下三个方面进行阐述:(1)转录因子与circRNAs在癌症领域中的前沿进展;(2)转录因子与circRNAs的调控关系;(3)转录因子与circRNAs在癌症中的治疗及应用前景。本文通过深入解析转录因子与circRNAs的调控机制,为癌症治疗提供理论依据,并为精准治疗和个性化医疗的发展开辟新途径。In the biological processes of malignant tumors,transcription factors and circular RNAs(circRNAs)play indispensable roles.Their molecular mechanisms reveal a complex network of gene regulation,with aberrant expression observed in various types of cancers affecting the digestive,reproductive,urinary,respiratory,nervous,and skeletal systems.Certain transcription factors can directly interact with circRNAs,influencing cancer initiation and progression,while circRNAs recruit transcription factors and bind to specific gene promoters or other regions to regulate gene transcription activity,thereby initiating a series of biological processes.This provides new research directions for the diagnosis,prognosis,and treatment of cancer in the future.However,research on these mechanisms remains in its infancy,particularly regarding to therapeutic and clinical applications,necessitating further exploration and validation.This paper will elucidate the topic through three main aspects:(1)the cutting-edge advancements of transcription factors and circRNAs in the field of cancer;(2)the regulatory relationships between transcription factors and circRNAs;(3)the therapeutic applications and future prospects of transcription factors and circRNAs in cancer.By deeply analyzing the regulatory mechanisms of transcription factors and circRNAs,this paper aims to provide a theoretical foundation for cancer treatment and to pave new pathways for the development of precision medicine and personalized healthcare.

关 键 词：转录因子 circRNAs 癌症进展 基因调控 治疗靶点 

分 类 号：R730.2[医药卫生—肿瘤]