红细胞SDE形态转变的实验研究和数值模型  

Experimental investigation and numerical models of red blood cell SDE transformations

作　　者：文海舟 胡国辉[1] 刘心悦 WEN Haizhou;HU Guohui;LIU Xinyue(School of Mechanics and Engineering Science/Shanghai Institute of Applied Mathematics and Mechanics/Shanghai Key Laboratory of Mechanics in Energy Engineering/Shanghai Frontier Science Center of Mechanoinformatics,Shanghai University,Shanghai 200072,China)

机构地区：[1]上海大学力学与工程科学学院,上海市应用数学和力学研究所,上海市能源工程力学重点实验室,上海市力学信息学前沿科学研究基地,上海200072

出　　处：《自然杂志》2024年第6期448-460,共13页Chinese Journal of Nature

基　　金：国家自然科学基金项目(12202258、12332016、12172209)。

摘　　要：红细胞的口形-双凹-刺突(stomatocyte-discocyte-echinocyte,SDE)形态转变对血液动力学及相关疾病有显著影响。红细胞膜的力学性质,如剪切模量、弯曲模量和膜蛋白连接能力等,对红细胞的形态起着至关重要的作用,并决定了红细胞在血液循环中的正常功能。如何基于红细胞微观结构的实验观测结果,建立一个能够描述SDE形态转变的数值模型来解释其生理学机制是一个具有挑战性的问题。文章概述了早中期关于红细胞SDE形态转变的实验和理论研究、近期基于物理化学因素和亚细胞结构变化的实验观测、红细胞黏弹性力学性质和血液黏度的测量方法,并介绍了各种研究红细胞SDE形态转变的数值模型,从实验和数值两个方面对红细胞SDE形态转变研究的进展和局限进行了综述,旨在为进一步深入研究SDE形态转变的力学生物学耦合机制提供一定的参考。The stomatocyte-discocyte-echinocyte(SDE)transformations in red blood cells(RBCs)have significant impacts on blood dynamics and related disorders.The mechanical properties of the RBC membrane,such as shear modulus,bending modulus,and protein binding capacity,play crucial roles in determining RBC shapes,collectively determining their normal functions in the circulatory system.Considering recent findings from microstructure experiments on RBCs,establishing a comprehensive numerical model capable of describing SDE shape transformations to elucidate the physiological mechanisms behind SDE morphological changes poses a challenging problem.This article provides an overview of experimental research and theoretical approaches concerning early intermediate-stage studies related to RBC SDE transformations.Additionally,it discusses recent experimental investigations on SDE morphological changes based on physicochemical factors and alterations in biological microstructures.Furthermore,it presents experimental methods for measuring the viscoelastic mechanical properties of RBCs and introduces various numerical models and methodologies employed in studying RBC SDE transformations.By reviewing research and developments in RBC SDE transformations from both experimental and numerical perspectives,this review aims to offer insights into establishing a comprehensive numerical model capable of describing SDE shape transformations to elucidate the physiological mechanisms behind SDE morphological changes.

关 键 词：红细胞 SDE形态转变 红细胞形态 细胞力学 红细胞微结构 血液黏度 生理学机制 数值模型 

分 类 号：O29[理学—应用数学] R318.01[理学—数学]