超声波萃取-气相色谱-串联质谱测定PM_(2.5)中18种多氯联苯  

Determination of 18 polychlorinated biphenyls in PM_(2.5) by ultrasonic extraction-gas chromatography-tandem mass spectrometry

作　　者：苏广宁[1] 王秦[2] 朱海燕 邓靖 鲁琳[1] 朱盼[1] 钟秀华[1] 梁少婷 罗志彬[1] 龙朝阳[1] 余胜兵[1] SU Guang-ning;WANG Qin;ZHU Hai-yan;DENG Jing;LU Lin;ZHU Pan;ZHONG Xiu-hua;LIANG Shao-ting;LUO Zhi-bin;LONG Chao-yang;YU Sheng-bing(Institute of Public Health Service Testing,Guangdong Provincial Center for Disease Prevention and Control,Guangzhou 511430,China;National Institute of Environmental Health,Chinese Center for Disease Control and Prevention;Center for Disease Prevention and Control of Baiyun District,Guangzhou)

机构地区：[1]广东省疾病预防控制中心卫生化验所,广州511430 [2]中国疾病预防控制中心环境与健康相关产品安全所 [3]广州市白云区疾病预防控制中心

出　　处：《环境卫生学杂志》2024年第12期1012-1019,共8页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：广东省医学科学技术研究基金项目(A2024654;B2023028;B2023036)。

摘　　要：目的建立同时测定大气细颗粒物(PM_(2.5))中18种多氯联苯化合物的方法。方法采样后的PM_(2.5)滤膜样品中加入氚代多氯联苯替代物,用超声波辅助提取,净化柱净化,气相色谱-串联质谱联用(GC-MS/MS)分析,内标法定量。结果18种多氯联苯的线性范围为1.8~45.0μg/L,线性关系良好(相关系数>0.997)。方法检出限在0.2~2.0 pg/m^(3),测定下限在0.8~8.0 pg/m^(3)。样品中多氯联苯低、中、高浓度加标回收率为64.6%~112.0%,相对标准偏差(RSD)在4.02%~10.90%。结论本方法操作简单、灵敏度高、稳定性好,能够满足大气细颗粒物中18种多氯联苯化合物同时检测的需求。Objective To establish a method for simultaneous determination of 18 polychlorinated biphenyl compounds in atmospheric fine particulate matter(PM_(2.5)).Methods Surrogates were added to PM_(2.5)quartz fiber filter samples for ultrasonic-assisted extraction,column purification,and quantification by gas chromatography-tandem mass spectrometry with internal standards.Results For the 18 polychlorinated biphenyls,the linear ranges were 1.8-45.0μg/L,with good linearity(correlation coefficients r>0.997);the detection limits were 0.2-2.0 pg/m^(3);the quantitation limits were 0.8-8.0 pg/m^(3);the recovery rates spiked at low,medium,and high concentrations were 64.6%-112.0%,and the relative standard deviations were 4.02%-10.90%.Conclusion The established method is simple,sensitive,stable,and reliable,which can meet the requirements for simultaneous measurement of 18 polychlorinated biphenyl compounds in atmospheric PM_(2.5).

关 键 词：多氯联苯 气相色谱-串联质谱 超声波萃取 细颗粒物 

分 类 号：R122[医药卫生—环境卫生学] R155[医药卫生—公共卫生与预防医学]