术前外周血清ALB及TP水平评估子宫内膜癌患者预后的价值  

Evaluation of the prognostic value of preoperative peripheral serum albumin and total protein levels in patients with endometrial cancer

作　　者：王薏清 刘聪慧 孟宗霞 周剑利 陈燕 WANG Yiqing;LIU Conghui;MENG Zongxia;ZHOU Jianli;CHEN Yan(Department of Gynecology,The Affiliated Hospital of North China University of Science and Technology,Tangshan,063000,China;Department of Anesthesiology,The Affiliated Hospital of North China University of Science and Technology,Tangshan,063000,China)

机构地区：[1]华北理工大学附属医院妇科,河北唐山063000 [2]华北理工大学附属医院麻醉科,河北唐山063000

出　　处：《华北理工大学学报（医学版）》2024年第6期427-431,共5页Journal of North China University of Science and Technology：Health Sciences Edition

基　　金：2022年政府资助临床医学优秀人才培养项目(编号:2022-180-3)。

摘　　要：目的探讨术前外周血白蛋白(ALB)及总蛋白(TP)水平作为子宫内膜癌(EC)患者生存及预后评估指标的可行性。方法收集2015年1月-2020年12月于华北理工大学附属医院行初始全面分期手术的89例EC患者的临床病理资料进行回顾性分析,通过门诊或电话随访至2024年6月,统计患者无病生存期(DFS)及总生存期(OS),采用Cox回归分析评估术前ALB与TP水平对于EC患者预后的影响。结果89例EC患者中位随访时间44个月(27~58个月),其中15例复发,4例死亡;中位DFS为44个月(15~58个月)。低ALB、低TP、术后病理分期为Ⅲ-Ⅳ期与低分化是影响EC患者复发的危险因素,且术前低ALB水平、FIGO分期为Ⅲ期和Ⅳ期均为独立危险因素,HR值分别为0.74、11.99、36.05,95%CI分别为0.60~0.90、2.49~57.82和4.74~274.08。低ALB、低TP和FIGOⅢ-Ⅳ期均是导致EC患者死亡的危险因素。结论术前外周血ALB和TP的水平可作为评估EC患者复发及预后的指标。Objective To explore the feasibility of preoperative peripheral serum albumin(ALB)and total protein(TP)levels as indicators for assessing survival and prognosis in patients with endometrial cancer(EC).Methods We retrospectively analyzed the clinicopathological data of 89 EC patients who underwent initial comprehensive staging surgery at The Affiliated Hospital of North China University of Science and Technology between January 2015 and December 2020.Patients were followed up via outpatient visits or telephone until June 2024 to collect their disease-free survival(DFS)and overall survival(OS).Cox regression analysis was used to assess the impact of preoperative ALB and TP levels on the prognosis of EC patients.Results The median follow-up duration for the 89 EC patients was 44 months(range:27-58 months),with 15 recurrences and 4 deaths observed.The median DFS was 44 months(range:15-58 months).Low ALB,low TP,postoperative pathological stage III-IV,and poorly differentiated EC were identified as risk factors for recurrence in EC patients.Preoperative low ALB levels,stage III,and stage IV were independent risk factors with hazard ratios(HRs)of 0.74,11.99,and 36.05,respectively,and 95%confidence intervals(CIs)of 0.60-0.90,2.49-57.82,and 4.74-274.08,respectively.Low ALB,low TP,and stages III-IV were all risk factors for death in EC patients.Conclusion Preoperative peripheral serum ALB and TP levels can serve as indicators for assessing recurrence and prognosis in EC patients.

关 键 词：子宫内膜癌 白蛋白 总蛋白 预后 

分 类 号：R737[医药卫生—肿瘤]