免疫检查点抑制剂联合放射治疗在胶质母细胞瘤治疗中的进展  

Advances in immune checkpoint inhibitors combined with radiation therapy in treatment of glioblastoma

作　　者：杜仕清 廖克曼 万权 孙翠平 鲁晓杰 DU Shiqing;LIAO Keman;WAN Quan;SUN Cuiping;LU Xiaojie(Neuroscience Research Center,Wuxi Medical College,Jiangnan University,Wuxi 214000,China)

机构地区：[1]江南大学附属中心医院神经外科研究所,无锡214000

出　　处：《临床神经外科杂志》2024年第6期689-693,共5页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金资助项目(82072791)。

摘　　要：胶质瘤是一种生存率极低的中枢神经系统原发性恶性肿瘤,近年新兴的免疫检查点抑制剂(ICI)等免疫疗法有望能改善胶质瘤治疗及预后,但由于血脑屏障阻断免疫细胞和胶质瘤固有免疫抑制等多种因素,ICI治疗仍处于起步阶段。放疗与ICI联合治疗有打破局限的潜力,通过放疗来协同ICI放大全身抗肿瘤免疫反应,如远隔效应。本综述阐述了放射治疗如何通过其免疫调节作用,表现出和ICI协同作用于肿瘤;还列出了胶质瘤中联合治疗临床研究进展和可能的发展方向。Glioma is a primary malignant tumor of central nervous system with very low survival rate.Immunotherapies such as immune checkpoint inhibitor(ICI),which have been newly developed in recent years,are expected to improve the treatment and prognosis of glioma.However,ICI treatment is still in its infancy due to a variety of factors such as blood-brain barrier blocking immune cells and glioma inherent immunosuppression.The combined treatment of radiotherapy and ICI have the potential to break the limitation.ICI can cooperate radiotherapy to amplify the systemic anti-tumor immune response,such as the distant effect.This review explains how radiation therapy,through its immunomodulatory effects,exhibits synergistic effects with ICI on tumors.The clinical research progress and possible development direction of combination therapy in glioma are also listed.

关 键 词：放射治疗 免疫检查点 联合治疗 远隔效应 胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤]