颅骨多发性骨髓瘤2例并文献复习  

Skull multiple myeloma:report of 2 cases and literature review

作　　者：张碧江 李经辉[1] ZHANG Bijiang;LI Jinghui(The Second Department of Neurosurgery,the First Affiliated Hospital of Kunming Medical University,Kunming 650000,China)

机构地区：[1]昆明医科大学第一附属医院神经外二科,昆明650000

出　　处：《临床神经外科杂志》2024年第6期712-716,共5页Journal of Clinical Neurosurgery

基　　金：云南省科技厅科技计划项目(202105AC160029)。

摘　　要：目的 探讨颅骨多发性骨髓瘤的临床表现和治疗方法。方法 回顾性分析昆明医科大学第一附属医院收治的2例颅骨多发性骨髓瘤患者的临床资料,并结合相关文献进行复习。结果 病例1患者左侧额颞顶部及右侧顶枕部病灶分两次行手术治疗,全切颅骨病灶,术后病理结果提示浆细胞瘤。术后进行放疗、化疗(VCD、VRD、VD方案),生存期4年。病例2患者手术切除顶骨中线区占位,术后病理结果提示浆细胞瘤。患者术后出现进行性肾功能不全,行透析后进一步放疗和化疗(PVD、DKD、KD方案),病情稳定。结论 对于颅骨多发性骨髓瘤患者,积极手术切除,术后个体化,有针对性的放化疗综合治疗对患者预后至关重要。Objective To investigate the clinical feature and treatment of skull multiple myeloma.Methods The clinical data of 2 patients with skull multiple myeloma were collected,including clinical features,imaging,pathological features,treatment and prognosis.The diagnosis and treatment were summarized and the related literatures were reviewed.Results Case 1:The lesions on the left frontotemporal top and the right parietal occipital region were treated by surgery in two times,and the skull lesions were completely removed.The postoperative pathological examination showed plasmacytoma.Postoperative radiotherapy and chemotherapy(VCD,VRD,VD regimen)were performed,and the survival time was 4 years.Case 2:Surgical resection of the middle line of the parietal bone.Postoperative pathological examination showed plasmacytoma.The patient developed progressive renal insufficiency after operation,and further radiotherapy and chemotherapy(PVD,DKD,KD regimen)were performed after dialysis,and the condition was stable.Conclusions For patients with multiple myeloma of the skull,active surgical resection,postoperative individualization,and targeted radiotherapy and chemotherapy are crucial to the prognosis of patients.

关 键 词：多发性骨髓瘤 浆细胞瘤 病例报道 

分 类 号：R739.41[医药卫生—肿瘤]