DCE-MRI联合血清TM4SF1、HER-2对乳腺癌的诊断价值  

Diagnostic value of DCE-MRI combined with serum TM4SF1 and HER-2 in breast cancer

作　　者：徐慧慧 霍英杰 王红辉 张翔辰 梁建利 邢巍 李国明 XU Huihui;HUO Yingjie;WANG Honghui;ZHANG Xiangchen;LIANG Jianli;XING Wei;LI Gouming(Department of Imaging,Hebei Petrochina Central Hospital,Langfang,Hebei 065000,China;Department of Breast Surgery,Hebei Petrochina Central Hospital,Langfang,Hebei 065000,China)

机构地区：[1]河北中石油中心医院影像科,河北廊坊065000 [2]河北中石油中心医院乳腺外科,河北廊坊065000

出　　处：《检验医学与临床》2024年第24期3714-3718,共5页Laboratory Medicine and Clinic

基　　金：河北省廊坊市科学技术研究与发展计划自筹经费项目(2022013124)。

摘　　要：目的分析动态增强磁共振成像(DCE-MRI)联合血清跨膜4超家族成员1(TM4SF1)、人表皮生长因子受体-2(HER-2)对乳腺癌(BC)的诊断价值。方法选取2021年1月至2022年12月该院收治的80例BC患者为BC组,选取同期在该院就诊的80例乳腺良性肿瘤患者为对照组。所有研究对象均接受DCE-MRI检查,计算容量转移常数(Ktrans)、血管外细胞外间隙容积比(Ve)、速率常数(Kep)。采用酶联免疫吸附试验检测血清TM4SF1、HER-2水平。采用受试者工作特征(ROC)曲线分析DCE-MRI联合血清TM4SF1、HER-2对BC的诊断价值。结果BC组和对照组DCE-MRI征象中形状、边缘、内部强化、时间信号强度曲线比较,差异均有统计学意义(P<0.05)。与对照组比较,BC组DCE-MRI定量指标中Ktrans、Kep明显升高,Ve明显降低,差异均有统计学意义(P<0.05)。与对照组比较,BC组血清TM4SF1和HER-2水平明显升高,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,DCE-MRI及血清TM4SF1、HER-2联合诊断BC的曲线下面积(AUC)大于Ktrans、Ve、Kep、TM4SF1和HER-2单独诊断的AUC(Z=7.107,P=0.008;Z=7.655,P=0.006;Z=9.546,P<0.001;Z=7.129,P=0.008;Z=10.333,P<0.001)。结论BC患者血清TM4SF1、HER-2水平升高,DCE-MRI联合TM4SF1、HER-2水平能够提高对BC的诊断价值。Objective To explore the diagnostic value of dynamic enhanced magnetic resonance imaging(DCE-MRI)combined with serum transmembrane 4 superfamily 1(TM4SF1)and human epidermal growth factor receptor-2(HER-2)for breast cancer(BC).Methods A total of 80 BC patients admitted to Hebei Petrochina Central Hospital from January 2021 to December 2022 were regarded as the BC group,while 80 patients with benign breast tumors who visited this hospital were regarded as the control group.DCE-MRI examination was performed on all patients,and volume transfer constant(K trans),extracellular space volume ratio(Ve),rate constant(K ep)were calculated.Enzyme linked immunosorbent assay was applied to detect the expression levels of serum TM4SF1 and HER-2.Receiver operating characteristic(ROC)curve was applied to analyze the diagnostic value of DCE-MRI combined with serum TM4SF1 and HER-2 for BC.Results There were significant differences between BC group and control group in shape,edge,internal enhancement and temporal signal intensity of DCE-MRI signs(P<0.05).Compared with those in the control group,the values of K trans and K ep as the quantitative indicators of DCE-MRI in the BC group increased obviously,while the value of Ve reduced obviously(P<0.05).Compared with those in the control group,the levels of serum TM4SF1 and HER-2 of patients in the BC group increased obviously(P<0.05).The ROC curve analysis results showed that the AUC value of DCE-MRI combined with serum TM4SF1 and HER-2 for diagnosing BC were bigger than those of K trans,V e,K ep,TM4SF1 and HER-2 alone(Z=7.107,P=0.008;Z=7.655,P=0.006;Z=9.546,P<0.001;Z=7.129,P=0.008;Z=10.333,P<0.001).Conclusion The expression levels of serum TM4SF1 and HER-2 of BC patients elevate,and DCE-MRI combined with TM4SF1 and HER-2 levels can improve the diagnostic value of BC.

关 键 词：动态增强磁共振成像 跨膜4超家族成员1 人表皮生长因子受体-2 乳腺癌 诊断 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]