Endogenous/exogenous dual stimulation“ROS engineering”amplification combined with autophagy-augmented for efficient ferroptosis therapy  

作　　者：Pengye Du Pengpeng Lei Yuan Liang Ran An Yi Wei Shuyu Liu Jianhao Zheng Hongjie Zhang 

机构地区：[1]State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China [2]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei 230026,China [3]Department of Chemistry,Tsinghua University,Beijing 100084,China

出　　处：《Nano Research》2025年第1期597-606,共10页纳米研究（英文版）

基　　金：supported by the financial aid from the National Natural Science Foundation of China(Nos.52371254 and 22020102003);the Program of Science and Technology Development Plan of Jilin Province of China(Nos.20220508076RC and YDZJ202302CXJD065).

摘　　要：“Reactive oxygen species(ROS)engineering”is one of the most promising anti-tumor treatments developed in recent years.Massive explosion of ROS will cause oxidative stress,thereby inducing tumor cell death.However,ROS accumulation in tumor cells is eliminated by endogenous cellular self-regulation strategies.In this work,a kind of endogenous/exogenous dual stimulation nanoagent noted as UMZC is developed.Fenton reaction occurs between NH_(2)-MIL-88B(Fe)contained in UMZC and the overexpression of endogenous H_(2)O_(2)to generate ROS,amplified by endogenous H_(2)S of colon tumor cells.In addition,NH_(2)-MIL-88B(Fe)also functions to deplete glutathione(GSH)for stopping it from consuming ROS.Upconversion nanoparticles at the core of UMZC convert near-infrared into visible light,which excites zinc phthalocyanine to initiate the photochemical reaction that generates more ROS,thus alleviating the lack of tissue penetration depth for visible light.Autophagy agonist chitosan oligosaccharides induce enhancement of cellular autophagy for disrupting cellular metabolic stress and the resistance to oxidative stress of tumor cells,allowing“ROS engineering”to fully exert anti-tumor effects.All of ROS generation,GSH depletion,and induced cellular autophagy caused by nanoagents have promoting effects on the occurrence of ferroptosis.Finally,the nanoagents show the ability to effectively treat colon tumors.

关 键 词：reactive oxygen species(ROS)engineering upconversion nanoparticles cellular autophagy ferroptosis tumor therapy 

分 类 号：R730.5[医药卫生—肿瘤]