生物牙根在牙再生研究中的进展  

Research progress of biological tooth roots regeneration

作　　者：张浩宇 郭维华 ZHANG Haoyu;GUO Weihua(State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,Chengdu 610041,China;Department of Pediatric Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;Yunnan Key Laboratory of Stomatology,The Affiliated Hospital of Stomatology,School of Stomatology,Kunming Medical University,Kunming 650500,China)

机构地区：[1]口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川成都610041 [2]四川大学华西口腔医学儿童口腔科,四川成都610041 [3]昆明医科大学附属口腔医院,云南省口腔医学重点实验室,云南昆明650500

出　　处：《口腔生物医学》2024年第6期346-351,共6页Oral Biomedicine

基　　金：国家自然科学基金(82270958);云南省重大科技项目(202302AA310038)。

摘　　要：牙缺失是口腔中最常见的疾病之一,目前临床上使用的修复方式均无法实现功能性牙再生。随着再生医学的发展,基于干细胞的组织工程技术成为了有前景的治疗策略。牙根是行使咀嚼功能的重要部分,是牙齿稳定发挥功能的基础,因此实现牙再生的关键就是实现功能性牙根再生。通过收集离体组织获取有高增殖和分化潜能的干细胞,结合生物相容性高的支架材料可以构建组织工程生物牙根,本文就对生物牙根的研究进展作一综述。Tooth loss is one of the most common diseases,and the existing clinical restorative methods fail to achieve functional tooth regeneration.With the advancement of regenerative medicine,stem cell-based tissue engineering techniques have emerged as promising therapeutic strategies.The tooth root is the basis for the stable function of the tooth.Therefore,a key challenge in tooth regeneration lies in the successful regeneration of functional tooth roots.By collecting tissues in vitro to obtain stem cells with high proliferation and differentiation potential,and combining them with biocompatible scaffold materials,it is possible to construct tissue-engineered biological tooth roots(bio-root).This review aims to provide an overview of recent advancements in the research on bio-root.

关 键 词：生物牙根 口腔再生医学 组织工程 干细胞 

分 类 号：R783.1[医药卫生—口腔医学]