骨髓间充质干细胞与巨噬细胞交互作用在骨再生中的研究进展  

Research progress of the interaction between bone marrow mesenchymal stem cells and macrophages in bone regeneration

作　　者：任春霞[1,2] 常蓓 殷皓宇 孙泺咏[2] 王化丽 宋少艺 孙宏晨 REN Chunxia;CHANG Bei;YIN Haoyu;SUN Luoyong;WANG Huali;SONG Shaoyi;SUN Hongchen(Department of periodontology,Hospital of Stomatology,Jilin University,Changchun 130021,China;Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,Changchun 130021,China;Department of Pediatric Dentistry,Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院牙周科,吉林长春130021 [2]吉林省牙发育及颌骨重塑与再生重点实验室,吉林长春130021 [3]吉林大学口腔医院儿童口腔科,吉林长春130021

出　　处：《口腔生物医学》2024年第6期352-356,共5页Oral Biomedicine

基　　金：国家自然科学基金青年项目(82201028);吉林省自然科学基金面上项目(YDZJ202301ZYTS099);吉林大学白求恩计划项目(2022B38)。

摘　　要：骨髓间充质干细胞(BMMSCs)不仅是骨再生的关键细胞来源,而且可以发挥免疫调节作用,招募并调控巨噬细胞的表型和功能。巨噬细胞不仅通过清除细胞碎片、坏死组织等,为骨再生创造良好的微环境,且可通过影响BMMSCs的迁移和分化参与骨再生。调控BMMSCs与巨噬细胞间的交互作用对于骨再生具有重要意义。本文就骨再生过程中BMMSCs与巨噬细胞交互作用及其调控策略的最新进展作一综述。The bone marrow mesenchymal stem cells(BMMSCs)are not only the key cell sources for bone regeneration,but also play an immunomodulatory role by recruiting and regulating the phenotype and function of macrophages.At the same time,macrophages not only create a good microenvironment for bone regeneration by removing cell debris and necrotic tissue,but also participate in bone regeneration by affecting the migration and differentiation of BMMSCs.Therefore,the regulation of the interaction between BMMSCs and macrophages is of great significance for bone regeneration.This article reviews the recent progress of the interaction between BMMSCs and macrophages and its regulatory strategies during bone regeneration.

关 键 词：骨髓间充质干细胞 巨噬细胞 骨再生 

分 类 号：R780.2[医药卫生—口腔医学]