Diminished functional segregation and resilience are associated with symptomatic severity and cognitive impairments in schizophrenia: a large-scale study  

作　　者：Haohao Yan Yiding Han Xijjia Xu Hongxing Zhang Yiqun He Guojun Xie Huabing Li Feng Liu Ping Li Jingping Zhao Wenbin Guo 

机构地区：[1]Department of Psychiatry,National Clinical Research Center for Mental Disorders,and National Center for Mental Disorders,The Second Xiangya Hospital of Central South Universitv Chanagsha Hunan China [2]Department of Psychiatry,the Affiliated Brain Hospital of Nanjing Medical University,Nanjing Brain Hospital,Nanjing,Jiangsu,China [3]Department of Psychiatry,The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan,China [4]Department of Clinical Psychology,Psychology School of Xinxiang Medical University,Xinxiang,Henan,China [5]Department of Psychosomatic Medicine,The Second Affliated Hospital of Xinxiang Medical University,Xinxiang,Henan,China [6]Department of Psychiatry,The Third People's Hospital of Foshan,Foshan,Guangdong,China [7]Department of Radiology,The Second Xiangya Hospital of Central South University,Changsha,Hunan,China [8]Department of Radiology,Tianjin Medical University General Hospital,Tianjin,China [9]Department of Psychiatry,Qiqihar Medical University,Qiqihar,Heilongjang,China

出　　处：《General Psychiatry》2024年第5期532-542,共11页综合精神医学（英文）

基　　金：funded by the National Natural Science Foundation of China(82171508);the Natural Science Foundation of Hunan(2023JJ30758).

摘　　要：Background The research findings on the topological properties of functional connectomes(TP-FCs)in patients with schizophrenia(SZPs)exhibit inconsistencies and contradictions,which can be attributed to limitations such as small sample sizes and heterogeneous data processing techniques.Aims To address these limitations,we conducted a large-scale study.Uniformdata processing flows were employed to investigate the aberrant TP-FCs and the associations between TP-FCs and symptoms or cognitions(A-TP-SCs)in SZPs.Methods The large-scale study included six datasets from four sites,involving 497 SZPs and 374 healthy controls(HCs).A uniform process for imaging data preprocessing and functional connectivity matrix configuration was used.ComBat was employed for data harmonisation,and various TPs were calculated.We explored between-group differences in brain functional integration(Fl)and functional segregation(FS)measured with TP-FCs,and conducted partial correlation analyses,with adjustments for age,gender and educational level,to identify A-TP-SCs.Results Comparedwith randomnetworks and HCs,SZPs maintained small-worldness and global FI capacity despite their compromised global FS capacity and resilience.A decline in nodal Fl and FS capacity was observed in sensory areas,whereas an increase in nodal FI capacity was found in regions associated with cognition and information integration.In addition,associations between TP-FCs and positive symptoms,negative symptoms or cognitive functions including speed of processing,visual learning and the ability to inhibit cognitive interference were identified in SZPs.Conclusions The identified A-TP-SCs verified that reductions in FS and resilience indicated pathological impairments in schizophrenia.The A-TP-SCs or TP-FCs,which measured the same attributes of the functional connectomes,exhibited high internal consistency,robustly reinforcing these findings.

关 键 词：finding limitations CONTRADICTION 

分 类 号：R749.3[医药卫生—神经病学与精神病学]