骨形态发生蛋白家族成员在成牙分化中作用的研究进展  

Research progress in the role of bone morphogenetic protein family members for odontogenic differentiation

作　　者：墨芸 邹慧儒 Mo Yun;Zou Huiru(Department of Stomatology,School of Medicine,Nankai University,Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Central Laboratory of Tianjin Stomatological Hospital,Tianjin 300041,China)

机构地区：[1]天津市口腔医院中心实验室,天津市口腔功能重建重点实验室,南开大学医学院口腔医学系,天津300041

出　　处：《国际生物医学工程杂志》2024年第5期485-491,共7页International Journal of Biomedical Engineering

基　　金：天津市自然科学基金(23JCYBJC01490,22JCYBJC01240);天津市卫生健康科技项目重点学科专项(TJWJ2024XK017)。

摘　　要：骨形态发生蛋白(BMP)家族成员众多,在细胞分化和组织形态发生方面具有多种调节功能,能够精准调控细胞增殖、分化以及凋亡等过程,其中BMP1、BMP2、BMP4、BMP7等BMP家族成员在成牙分化中发挥重要作用。通过深入研究BMP在牙齿发育及修复再生中的表达与调控机制,有助于更好地理解牙齿形成的生物学过程,为牙体缺损的修复再生提供理论支持。然而,BMP的临床应用仍面临着诸多挑战,如何在成牙分化过程中精准调控BMP的表达与活性,仍有待深入研究。因此,主要综述了BMP家族成员在成牙分化中的作用研究,以期为探索BMP应用于牙体缺损修复再生治疗新策略提供参考。The bone morphogenetic protein(BMP)family has numerous members that play various regulatory roles in cell differentiation and tissue morphogenesis.They can precisely regulate cell proliferation,differentiation,apoptosis,and other processes.Notably,the members of the BMP family,such as BMP1,BMP2,BMP4,and BMP7,etc.,play significant roles in the odontoblast differentiation.By delving into the expression and regulatory mechanisms of BMP during tooth development and reparative regeneration,a deeper understanding of the biological processes involved in tooth formation can be gained,providing theoretical support for the repair and regeneration of dental defects.However,the clinical application of BMP still faces numerous challenges,and how to precisely regulate the expression and activity of BMP during odontogenic differentiation remains to be further studied.In this review,the research progress in the role of the BMP family members for odontogenic differentiation was summarized,with a view to providing some reference for exploring new therapeutic strategies of BMP application in the repair and regeneration of dental defect.

关 键 词：骨形态发生蛋白 成牙分化 牙体缺损 牙齿再生 

分 类 号：R78[医药卫生—口腔医学]