岩藻黄素抗光老化剂型的制备及其理化指标和性能检测  

Preparation of Fucoxanthin Anti-photoaging Dosage Form and ItsPhysical and Chemical Index and Performance Test

作　　者：刘关童 王瑞 汪鎔金 张雷芳 LIU Guantong;WANG Rui;WANG Rongjin;ZHANG Leifang(School of Food and Pharmaceutical Sciences,Zhejiang Ocean University,Zhoushan 316000)

机构地区：[1]浙江海洋大学食品与药学学院,舟山316000

出　　处：《食品工业》2024年第11期60-66,共7页The Food Industry

摘　　要：从海带中提取岩藻黄素,并开发一种具有抗氧化、保湿和改善皮肤弹性功能的精华液。采用甲醇浸提法提取岩藻黄素,并通过硅胶柱层析法进行分离纯化。通过薄层色谱法和红外光谱法鉴定纯化后的岩藻黄素。评估岩藻黄素的细胞毒性、抗氧化活性(DPPH自由基和羟自由基清除活性)以及保湿和改善皮肤弹性的功效。利用正交试验设计优化精华液处方,并进行理化指标和活性检测。试验成功从海带中提取并纯化岩藻黄素,提取率为7.00%。岩藻黄素对HaCaT细胞毒性较小,并表现出较强的抗氧化活性。通过正交试验确定精华液的最佳处方:甘油聚醚16%、双丙甘醇8%、羧甲基纤维素钠0.4%。最佳处方制备的精华液理化指标符合国家标准,且具有显著的抗氧化、保湿和改善皮肤弹性的功效。试验开发的岩藻黄素精华液具有良好的护肤功效,有望用于开发新型抗衰老化妆品。Aim to extract fucoxanthin from kelp and develop a serum with antioxidant,moisturizing,and skin elasticityimproving properties.Fucoxanthin was extracted using methanol extraction and purified through silica gel column chromatography.The purified fucoxanthin was identified by thin-layer chromatography(TLC)and infrared spectroscopy(IR).The cytotoxicity of fucoxanthin on HaCaT cells,its antioxidant activity(DPPH radical scavenging activity and hydroxyl radical scavenging activity),as well as its moisturizing and skin elasticity-improving effects were evaluated.An orthogonal experimental design was used to optimize the serum formulation,followed by physicochemical index testing and efficacy assessment.Fucoxanthin was successfully extracted and purified from kelp with an extraction yield of 7.00%.Fucoxanthin exhibited low cytotoxicity towards HaCaT cells and demonstrated strong antioxidant activity.The optimal serum formulation determined through orthogonal experiments consisted of 16%glycerol polyether,8%dipropylene glycol,and 0.4%sodium carboxymethyl cellulose.The physicochemical indices of the optimized serum met national standards,showing significant antioxidant,moisturizing,and skin elasticity-improving effects.The fucoxanthin-enriched serum developed in this study exhibits excellent skincare benefits,making it a promising candidate for new anti-aging cosmetic products development.

关 键 词：岩藻黄素 抗氧化 精华液 

分 类 号：TQ658[化学工程—精细化工]