干眼的症状、体征与焦虑及抑郁相关性的临床研究  

The correlation of dry eye symptomss and signs with anxiety and depression

作　　者：汪毅仁 江晓丹[2] 李佳曦 赵天瑶 李学民[2] Wang Yiren;Jiang Xiaodan;Li Jiaxi;Zhao Tianyao;Li Xuemin(Peking University Third Hospital,Beijing 100191,China;Department of Ophthalmology,Peking University Third Hospital,Beijing Key Laboratory of Reconstruction,Protection and Rehabilitation of Eye Nerve Injury,Beijing 100191,China)

机构地区：[1]北京大学第三医院,100191 [2]北京大学第三医院眼科中心,眼部神经损伤的重建保护与康复北京市重点实验室,100191

出　　处：《中华眼科医学杂志（电子版）》2024年第4期212-216,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：首都卫生发展科研专项项目(首发2024-240913)。

摘　　要：目的探讨干眼症状、体征与焦虑及抑郁之间的相关性。方法收集2021年6月至2021年12月就诊于北京大学第三医院眼科中心患者83例(166只眼)进行研究。其中,男性9例(18只眼),女性42例(84只眼)。年龄24~83岁,平均年龄为(51.0±16.1)岁。根据干眼诊断标准分为干眼组和对照组。应用眼表疾病指数问卷(OSDI)评估受试者干眼症状,应用医院用焦虑抑郁评分量表(HADS)测量患者焦虑评分和抑郁评分,分别应用OculusKeratograph5M眼表分析仪和角膜共聚焦激光扫描显微镜收集患者睑板腺红外成像照片及角膜神经图片,并应用ImageJ软件测量睑板腺面积指数和角膜神经密度。经检验,患者OSDI评分、HADS焦虑分数、HADS抑郁分数、睑板腺指数及角膜神经密度符合正态分布,以x珋±s表示。干眼组和对照组患者各项指标的差异性采用独立样本t检验,干眼组患者的干眼症状、体征指标与HADS评分之间的相关性采用Pearson分析,干眼症状、体征对HADS评分的预测模型采用二元Logistics回归分析。结果干眼组和对照组患者OSDI评分分别为(22.7±18.0)分和(28.8±16.4)分,其差异具有统计学意义(t=1.54,P<0.05)。干眼组和对照组患者睑板腺指数分别为(0.19±0.06)和(0.22±0.07),其差异具有统计学意义(t=-2.20,P<0.05)。干眼组和对照组患者角膜神经密度分别为(2346.7±783.0)μm/mm^(2)和(2419.8±386.5)μm/mm^(2),其差异具有统计学意义(t=0.56,P<0.05)。干眼组和对照组患者HADS焦虑分数分别为(7.5±4.4)分和(1.9±1.8)分,其差异具有统计学意义(t=9.49,P<0.05)。干眼组和对照组患者HADS抑郁分数分别为(7.5±3.1)分和(3.5±2.6)分,其差异具有统计学意义(t=6.08,P<0.05)。干眼组患者HADS焦虑分数与OSDI评分有弱相关性且呈正相关,与角膜神经密度有弱相关性且呈负相关,与睑板腺指数有中等相关性且呈负相关,其相关性均具有统计学意义(r=0.37,-0.35,-0.43;P<0.05)。干眼组患�Objective To explore the correlation between dry eye symptoms,signs and anxiety and depression.Methods A total of 83 patients(166 eyes)in the Department of Ophthalmology of Peking University Third Hospital from June 2021 to December 2021 were collected.There were 9 males(18 eyes)and 42 females(84 eyes)with the average age of(51.0±16.1)years(ranged from 24 to 83 years).According to the diagnostic criteria of dry eye,the patients were divided into dry eye group and control group.The dry eye symptoms of the subjects were evaluated by the ocular surface disease index questionnaire(OSDI).The anxiety and depression scores of the patients were measured by the hospital anxiety and depression rating scale(HADS).The infrared images of meibomian gland and corneal nerve images were collected by Oculus Keratograph 5M eye surface analyzer and corneal confocal laser scanning microscope,respectively.The meibomian gland area index and corneal nerve density were measured by ImageJ software.After examination,the OSDI score,HADS anxiety score,HADS depression score,meibomian gland index and corneal nerve density of the patients conformed to the normal distribution,and were expressed as x±s.The difference of each index between the dry eye group and the control group was tested by independent sample t test.The correlation between the dry eye symptoms,signs and HADS score in the dry eye group was analyzed by Pearson.The prediction model of dry eye symptoms and signs on hads score was analyzed by binary Logistics regression.Results The OSDI scores of patients in the dry eye group and the control group were(22.7±18.0)and(28.8±16.4)points,respectively,with a statistically significant difference(t=1.54,P<0.05).The meibomian gland index of patients in the dry eye group and the control group was(0.19±0.06)and(0.22±0.07),respectively,with a statistically significant difference(t=-2.20,P<0.05).The corneal nerve density of patients in the dry eye group and the control group was(2346.7±783.0)μm/mm^(2)and(2419.8±386.5)μm/mm^(2),respectiv

关 键 词：干眼 焦虑 抑郁 睑板腺 角膜神经 

分 类 号：R777.34[医药卫生—眼科]