乳腺癌患者新辅助化疗对苯磺顺阿曲库铵肌松效应的影响  

Effect of neoadjuvant chemotherapy on myosonant effect of benzyl catracurium in patients with breast cancer

作　　者：李晓慧 陈学新 尤小刚 马富强 李文彬 Li Xiaohui;Chen Xuexin;You Xiaogang;Ma Fuqiang;Li Wenbin(Department of Anesthesiology and Perioperative Medicine,General Hospital of Ningxia Medical University,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学总医院肿瘤医院麻醉与围术期医学科,银川750004

出　　处：《山西医药杂志》2024年第23期1768-1772,共5页Shanxi Medical Journal

基　　金：宁夏医科大学校级科研项目(XM2018166)。

摘　　要：目的分析乳腺癌患者新辅助化疗对苯磺顺阿曲库铵肌松效应的影响效果。方法于2018年1月至2018年12月,回顾性分析并研究了本院收治的72例乳腺癌患者,美国麻醉医师协会(ASA)分级Ⅰ或Ⅱ级,年龄30~60岁,体质指数(BMI)在18~29 kg/m^(2),依据患者手术之前是否接受了新辅助化疗将其分入2个小组,观察组(接受新辅助化疗组)38例、对照组(未接受新辅助化疗组)34例。术前新辅助化疗方法在观察组中进行实施,而对照组则在术前不进行新辅助化疗。分组探究肌松情况、体征变化情况、苯磺顺阿曲库铵的使用情况、平均输注的速率和发生的不良反应。结果2组t1、t2、t3、t4、t5、t6、恢复指数(RI)时刻心率、平均动脉压(MAP)及血氧饱和度(SpO2)体征水平数据显示差异无统计学意义(P>0.05);2组0~90 min苯磺顺阿曲库铵的使用量均降低,但观察组在0~30 min、31~60 min、61~90 min苯磺顺阿曲库铵的使用量多于对照组,观察组平均输注速率高于对照组(P<0.05);2组不良反应发生率相比差异无统计学意义(P>0.05)。结论术前行新辅助化疗乳腺癌根治手术患者,术中苯磺顺阿曲库铵平均输注速度大,用量增多。Objective To analyze the effect of neoadjuvant chemotherapy on the myosonant effect of benzyl catracurium in breast cancer patients.Methods Retroretrospective analysis of 72 breast cancer patients admitted to our hospital from January 2018 to December 2018,with ASA grade I or grade,30 to 60 years old,body quality index(BMI)of 18 to 29 kg/m^(2).Patients were assigned to two groups after receiving neoadjuvant chemotherapy before surgery,38 cases in observation group(received neoadjuvant chemotherapy)and 34 cases in control group(no received neoadjuvant chemotherapy).Comparison of muscle relaxation,changes in physical signs,use of benzene and atracurium,rate of average infusion and adverse reactions.Results Heart rate,MAP and SpO2 sign levels at t1,t2,t3,t4,t5,t6 and RI time data showed no difference between the two groups(P>0.05);The use of atracuronium decreased from 0 to 90 min in both groups,but the use of atracuronium at 0 to 30 min,31 to 60 min and 61 to 90 min was more than that of the control group,and the average infusion rate of the observation group was higher than that of the control group(P<0.05);There was no difference in the incidence of adverse effects between the two groups(P>0.05).Conclusion In patients with neoadjuvant chemotherapy,the average infusion rate of benzyl catracurium was large and the amount increased.

关 键 词：乳腺癌 新辅助化疗 苯磺顺阿曲库铵 肌松效应 

分 类 号：R737.9[医药卫生—肿瘤]