补充益生菌对妊娠期糖尿病高危孕妇抑郁状况的影响  

EFFECT OF PROBIOITIC SUPPLEMENTATION ON DEPRESSION STATUS IN PREGNANT WOMEN AT HIGH RISK OF GESTATIONAL DIABETES MELLITUS

作　　者：王金晶 孙霁寒 苗苗[2] 戴永梅[2] 王煚楠 孙桂菊 WANG Jin-jing;SUN Ji-han;MIAO Miao;DAI Yong-mei;WANG Jiong-nan;SUN Gui-ju(Key Laboratory of Environmental Medicine Engineering,Ministry of Education/Department of Nutrition and Food Hygiene,School of Public Health,Southeast University,Nanjing 210009,China;Nanjing Maternal and Child Health Hospital,Nanjing 210004,China)

机构地区：[1]东南大学公共卫生学院环境医学工程教育部重点实验室/营养与食品卫生学系,南京210009 [2]南京市妇幼保健院,南京210004

出　　处：《营养学报》2024年第4期328-333,共6页Acta Nutrimenta Sinica

基　　金：江苏省研究生科研与实践创新项目(No.SJCX21_0088)。

摘　　要：目的观察益生菌对妊娠期糖尿病高危孕妇抑郁状况的影响,为妊娠期糖尿病高危孕妇抑郁状况改善提供新思路。方法选择2020年6月至2021年6月就诊于南京市妇幼保健院具有妊娠期糖尿病高危因素的446例孕早期(15 w内)孕妇作为研究对象,随机分为益生菌组和安慰剂对照组各223例。从孕早期(15 w内)持续干预至孕晚期,每日服用益生菌或安慰剂一袋。通过基本情况调查问卷、抑郁自评量表采集入组时(15 w内),孕中期(24~28 w)和孕晚期(34~36w)妊娠期糖尿病高危孕妇的抑郁状况。结果干预22w后,益生菌组抑郁状况改善,和对照组相比有统计学差异(P<0.05);与干预前相比,存在抑郁状况的妊娠期糖尿病高危孕妇在孕中期和孕晚期的抑郁状况均显著性下降(P<0.01)。结论通过补充益生菌可以改善妊娠期糖尿病高危孕妇的抑郁状况。Objective To observe the effect of probiotics on the depression status in pregnant women at high risk of gestational diabetes mellitus(GDM),and to provide new ideas for improving the depression status.Methods A total of 446 pregnant women with high risk factors of GDM in Nanjing Maternal and Child Health Hospital from June 2020 to June 2021 were randomly divided into probiotics group(n=223)and placebo control group(n=223).From the first trimester(within 15 weeks)to the third trimester until delivery,one sachet of probiotics or placebo was administered per day.The depression status of the high-risk GDM groups with in the second trimester(24-28 weeks)and third trimester(34-36 weeks)at the time of enrollment(within 15 weeks)was evaluated through questionnaire and the depression self-rating scale.Results After 22 weeks of intervention,the depression status of the probiotic group was significantly improved compared with that of the control group(P<0.05).Compared with before the intervention,the depression status of the depressed pregnant women in the high risk GDM group decreased significantly after 12 and 22 weeks of intervention(P<0.01).Conclusion The depression status of the pregnant women at high risk of GDM can be improved by supplementing probiotics.

关 键 词：益生菌 抑郁 妊娠期糖尿病高危孕妇 

分 类 号：R151.2[医药卫生—营养与食品卫生学]