健康母亲不同泌乳阶段的母乳维生素E含量系统综述  

THE LEVEL OF VITAMIN E IN BREAST MILK DURING DIFFERENT STAGES OF LACTATION:A SYSTEMATIC REVIEW

作　　者：蒋燕 席元第 王纤云[2] 张环美 任向楠 赵艾 赖建强[1,3,4] 肖荣 JIANG Yan;XI Yuan-di;WANG Xian-yun;ZHANG Huan-mei;REN Xiang-nan;ZHAO Ai;LAI Jian-qiang;XIAO Rong(China-DRIs Research Group on Human Milk Composition,Beijing 100050;School of Public Health,Capital Medical University,Beijing 100069;National Institute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050;Key Laboratory of Human Milk Science,Chinese Center for Disease Control and Prevention,Beijing 100050;Wanke School of Public Health,Tsinghua University,Beijing 100084,China)

机构地区：[1]中国DRIs母乳成分研究工作组,北京100050 [2]首都医科大学公共卫生学院,北京100069 [3]中国疾病预防控制中心营养与健康所,北京100050 [4]中国疾病预防控制中心母乳科学研究重点实验室,北京100050 [5]清华大学万科公共卫生与健康学院,北京100084

出　　处：《营养学报》2024年第4期398-406,共9页Acta Nutrimenta Sinica

基　　金：中国营养学会科研基金——海普诺凯母婴营养科研专项基金(No.CNS-HPNK2021-89);国家自然科学基金(No.82273620,81973018,82003459);中华人民共和国国家卫生健康委员会微量元素与营养重点实验室(No.WLKFZ202201)。

摘　　要：目的为了解我国及国外不同泌乳阶段的母乳维生素E含量,对健康母亲不同泌乳阶段的母乳维生素E含量进行系统综述。方法计算机检索中国知网、万方数据知识服务平台、维普、PubMed、CochraneLibrary、Webof Science、Embase中英文数据库有关母乳维生素E含量的文献,检索时间截止至2021年4月30日。对纳入文献采用澳大利亚循证保健中心(JBI)循证医学工具进行质量评价。所有数据根据样品量进行加权后,计算样本量加权均数(Means)和标准差(SDs)。结果共纳入53篇文献,描述性研究46篇,病例对照研究1篇,非随机对照研究1篇,随机对照研究5篇。中国乳汁样本文献:初乳维生素E含量为(8.01±4.78)mgα-TE/L,过渡乳维生素E含量为(4.00±2.14)mgα-TE/L,成熟乳维生素E含量(为3.02±1.80)mgα-TE/L。国外乳汁样本文献:初乳维生素E含量为(13.33±7.50)mgα-TE/L,过渡乳维生素E含量为(4.40±2.50)mgα-TE/L,成熟乳维生素E含量为(3.08±1.90)mgα-TE/L。结论母乳中的维生素E含量随泌乳阶段的不同而变化,初乳维生素E含量显著高于过渡乳和成熟乳。欧美国家的初乳维生素E含量高于包括我国在内的亚洲国家,可能与遗传背景和饮食差异等因素有相关。现有研究过渡乳的采集时间存在差异,有必要后续补充最新研究及时更新。国内外成熟乳维生素E的含量较为接近,现有研究支持其含量在产后约12d至4-6月内趋于稳定,但尚需更多数据支持。Objective To summarize the level of vitamin E in breast milk at different lactation stages in health mothers in China and abroad.Methods Databases of CNKI,Wanfang Data,VIP,PubMed,Cochrane Library,Web of Science and Embase were searched for articles assayed vitamin E levels in breast milk that published before April 30,2021.The quality of studies was assessed using the Joanna Briggs Institute(JBI)critical appraisal checklist.Results Of all publications identified,fifty-three were eligible for final analysis.Forty-six descriptive studies,one case-control study,one non-randomized controlled trials,and five randomized controlled trials were included.Previous studies showed that vitamin E concentrations among Chinese healthy mothers in colostrum,transitional and mature milk were(8.01±4.78)mgα-TE/L,(4.00±2.14)mgα-TE/L,(3.02±1.80)mgα-TE/L,respectively.Vitamin E concentrations in colostrum,transitional milk,and mature milk among foreigner healthy mothers were(13.33±7.50)mgα-TE/L,(4.40±2.50)mgα-TE/L,(3.08+1.90)mgα-TE/L,respectively.Conclusion The level of vitamin E in breast milk decreased during lactation.The vitamin E concentration of colostrum in Asia countries including China is obviously lower than that in Western countries,which may be closely associated with dietary habits,diversity between individuals and other factors.Different definitions of transitional milk collection time could produce different results for vitamin E content in breast milk,and thus latest studies are necessary to be collected for update timely in the future.There was little difference in the content of vitamin E in mature milk between China and foreign countries,but the stability of vitamin E level in breast milk from 12 days to 4-6 months postpartum still need more studies to investigate.

关 键 词：维生素E Α-生育酚 母乳 哺乳期 

分 类 号：R153.2[医药卫生—营养与食品卫生学]