原花青素在帕金森病模型中的神经保护作用实验研究系统评价  

SYSTEMATIC EVALUATION OF EXPERIMENTAL STUDIES ON THE NEUROPROTECTIVE EFFECTS OF PROANTHOCYANIDINS IN PARKINSON’S DISEASE MODELS

作　　者：张秀文 张小强[1,2] 黄文迪 丁岚 ZHANG Xiu-wen;ZHANG Xiao-qiang;HUANG Wen-di;DING Lan(School of Public Health,Southeast University,Nanjing 210009,P.R.China;Key Laboratory of Environmental Medicine Engineering of Ministry of Education,Southeast University,Nanjing 210009,P.R.China)

机构地区：[1]东南大学公共卫生学院,南京210009 [2]东南大学环境医学工程教育部重点实验室,南京210009

出　　处：《营养学报》2024年第4期407-413,416,共8页Acta Nutrimenta Sinica

基　　金：中央高校基本科研业务费专项资金资助和江苏省普通高校研究生科研创新计划资助项目(No.SJZZ16_0034)。

摘　　要：原花青素,也叫缩合单宁,是天然来源的多酚化合物的代表物质,广泛存在于多种水果和蔬菜中。越来越多的证据表明,原花青素可以通过多种机制来预防帕金森病,已被用于帕金森病的实验性治疗中。但不同学者对于原花青素治疗帕金森病的作用效果的研究存在一定差异,因此在这项研究中,我们采用系统回顾的方法来全面评估原花青素在实验性帕金森病中的疗效。旨在探讨原花青素对机体的神经保护作用,为帕金森病的防治提供参考,为原花青素资源的开发利用提供科学依据。Proanthocyanidins,also called condensed tannins,are representative substances of polyphenolic compounds of natural origin and are widely found in a variety of fruits and vegetables.There is increasing evidence that proanthocyanidins can prevent Parkinson's disease through multiple mechanisms and have been used in experimental treatments of Parkinson's disease.However,there are some inconsistencies regarding the effects of proanthocyanidins on Parkinson's disease.In this study,we used a systematic appproach to comprehensively assess the efficacy of proanthocyanidins in experimental Parkinson's disease models.We aimed to investigate the neuroprotective effects of proanthocyanidins,to provide a reference for the prevention and treatment of Parkinson's disease,as well as a scientific basis for the development and utilization of proanthocyanidin resources.

关 键 词：PAC 帕金森病 系统评价 

分 类 号：R151.41[医药卫生—营养与食品卫生学]